尼可地尔针剂在老年非ST抬高型急性冠脉综合征的临床疗效  

Efficacy of nicorandil injection in elderly patients with non-ST-segment elevation acute coronary syndrome

作　　者：周仑[1] 王昭昭[1] 凃玲[1] ZHOU Lun WANG Zhao-zhao TU Ling(Tongji Hospital Affiliated to Huazhong University of Science and Technolo- gy, Huhei Wuhan 430030, Chin)

机构地区：[1]华中科技大学同济医学院附属同济医院老年科,湖北武汉430030

出　　处：《中国医院药学杂志》2017年第6期541-544,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨尼可地尔针剂在老年非ST抬高型急性冠脉综合征的临床疗效。方法:将46例非ST抬高型急性冠脉综合征患者随机分为硝酸甘油治疗组和尼可地尔治疗组,治疗3~5 d,分别观察治疗前后心绞痛的发作频次、持续时间、心电图改变、心脏超声,评估治疗前后射血分数的改变、高敏C反应蛋白(HsCRP)以及治疗过程中的不良反应。结果:与硝酸甘油治疗组相比,尼可地尔针剂治疗组能进一步改善患者心绞痛的症状,同时对心肌缺血所致的ST-T改变也有改善症状。此外尼可地尔治疗组左室射血分数也有进一步的提高,HsCRP进一步下降,同时其头痛、面部潮红、心悸等不良反应比硝酸甘油组减少(P<0.05)。结论:尼可地尔针剂在老年非ST抬高型急性冠脉综合征的应用是安全有效的。OBJECTIVE To study the therapeutic effects of nicorandil injection in elderly patients with non-ST-segment elevation acute coronary syndrome.METHODS Totally 46 elderly patients with non-ST-segment elevation acute coronary syndrome were divided to nitroglyerin group and nicorandil group.After these patients were treated for 3 to 5 days,angina frequency,duration,change of ECG and heart ejection fraction,high sensitivity C-reactive protein（HsCRP）and adverse reactions were detected.RESULTS Compared with nitroglycerin group,angina pectoris and ST-T change of ECG were further relieved in the nicorandil group（P〈0.05）.In addition,left ventricular ejection fraction was further improved,HsCRP falled（P〈0.05）.Adverse reactions,such as headache,facial hot flashes,palpitation,were further reduced（P〈0.05）.CONCLUSION Nicorandil injection is a safe and effective in elderly patients with non ST elevation acute coronary syndrome.

关 键 词：老年患者 非ST抬高型急性冠脉综合征 尼可地尔 

分 类 号：R972[医药卫生—药品]