注射用泮托拉唑钠与8种常用注射剂的配伍稳定性考察  

Compatibility of pantoprazole sodium for injection combined with eight common injections

作　　者：许锦英[1] 孙华[2] 梁大虎[2] 殷勤[1] 盛雪鹤 刘孟雪 姚瑶[1] 周露露[1] 黄越 XU Jin-ying SUN Hua LIANG Da-hu YIN Qin SHENG Xue-he LIU Meng-xue YAO Yao ZHOU Lu-lu HUANG Yue(Department of Pharmacy,Second Affiliated Hospital of Wannan Medical College,Anhui Wuhu 241000, China Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College, Anhui Wuhu 241000, China Department of Biological Inspection,Wuhu Institute for Food and Drug Inspection, Anhui Wuhu 241006, China)

机构地区：[1]皖南医学院第二附属医院药剂科,安徽芜湖241000 [2]皖南医学院弋矶山医院临床药学部,安徽芜湖241000 [3]芜湖市食品药品检验所生测室,安徽芜湖241006

出　　处：《中国医院药学杂志》2017年第6期553-557,共5页Chinese Journal of Hospital Pharmacy

基　　金：皖南医学院中青年科研基金自然科学类项目(编号:WK2014F44)

摘　　要：目的:考察室温条件下注射用泮托唑钠与8种临床常用药物的配伍稳定性。方法:建立了泮托拉唑钠高效液相含量测定方法,模拟临床应用,以0.9%的氯化钠溶液为溶媒,按比例分别将注射用泮托拉唑钠与肌苷注射液、维生素B6注射液、维生素K_1注射液、注射用辅酶A、氨苯甲酸注射液、酚磺乙胺注射液、门冬氨酸钾镁注射液、注射用ATP8种临床常见药物混合,在混合后即刻、0.5,1,2 h 4个时间点考察泮托拉唑含量、外观、不溶性微粒、溶液pH值的变化。结果:泮托拉唑钠与氨苯甲酸、酚磺乙胺、维生素B6配伍后2 h内含量明显下降。结论:泮托拉唑对pH敏感,注射用泮托拉唑钠不宜与氨苯甲酸、酚磺乙胺、维生素B6配伍,序贯使用时需冲洗管路。OBJECTIVE To investigate the compatibility of pantoprazole combined with eight commonly administered injectables under ambient room temperature.METHODS The HPLC method for pantoprazole determination was established.Simulated Y-site compatibility evaluation was accomplished by mixing pantoprazole with an alternative intravenous medication（inosine injection,vitamin B_6 injection,vitamin K_1 injection,coenzyme A for injection,aminomethylbenzoic acid injection,ethamsylate injection,potassium magnesium aspartate injection and adenosine disodium triphosphate injection）in NS,and then the mixture was stored in a polypropylene syringe for 2 h.The concentration of pantoprazole,appearance,the number of insoluble particles and pH value of pantoprazole in admixtures were observed immediately and at 0.5,1 and 2 h.RESULTS The content of pantoprazole declined obviously in two hours after mixing with aminomethylbenzoic acid injection,etamsylate and vitamin B_6 injection,respectively.CONCLUSION The pantoprazole injection is sensitive to pH value,and should not be administered concomitantly with aminomethylbenzoic acid injection,etamsylate or vitamin B_6 injection.Furthermore,the pipeline should be cleaned when pantoprazole is sequential Y-site administered with any one of these products.

关 键 词：配伍稳定性 泮托拉唑 氨苯甲酸 酚磺乙胺 维生素B6高效液相法 

分 类 号：R913[医药卫生—药学]