右美托咪定联合舒芬太尼用于小儿大面积烧伤削痂植皮术后镇痛的临床研究  

Analgesia with dexmedetomidine and sufentanil after tangential excision of eschar and skin grafting in children with large area of burn wound

作　　者：岑相如 黎达锋 岑俏丹 黄华佑 

机构地区：[1]阳江市人民医院麻醉科,529500

出　　处：《国际医药卫生导报》2017年第7期1049-1051,共3页International Medicine and Health Guidance News

摘　　要：目的探讨右美托咪定联合舒芬太尼用于,,bJL大面积烧伤削痂植皮术后的镇痛效果。方法选取本院2015年2月至2016年5月收治的拟行削痂植皮术的患儿48例，按照随机数字法分为对照组与观察组，每组24例。观察组术后应用右美托咪定联合舒芬太尼镇痛，对照组仅用舒芬太尼镇痛，观察并比较48h后两组镇痛效果和不良反应。结果经过48h观察与评估，观察组Ramsay评分静态（3．8±0．5）、动态（3．1±0．2），明显高于对照组的（1．6±0．2）和（1．3±0．3）μg；观察组动静态镇静率均为100．0％，明显高于对照组的58．3％和41．7％；观察组的舒芬太尼用量（41．47±3．26）μg，明显低于对照组的（58．32±3．79）；观察组补救镇痛率为0．0％，明显低于对照组的37．5％；观察组术后不良反应发生率为0．0％，明显低于对照组的12．5％；以上差异具有统计学意义（均P〈0．05）。结论右美托咪定联合舒芬太尼可显著改善大面积烧伤患儿削痂植皮术后的镇痛效果，减少不良反应。Objective To analyze the effect of analgesia with dexmedetomidine and sulfentanyl after tangential excision of eschar and skin grafting in children with large area of burn wound. Methods 48 children undertaking tangential excision of eschar and skin grafting at our hospital from February, 2015 to May, 2016 were selected and randomly divided into a control group and an observation group using random number method, 24 cases for each group. The observation group took analgesia with the dexmedetomidine and sulfentanyl after the operation and the control group with sulfentanyl. The analgesia effects and the adverse reactions were compared and the data were analyzed by SPSS19.0. Results 48 h after analgesia, the static and dynamic scores of Ramsay were （3.8 ± 0.5） and （3.1 ± 0.2） in the observation group and were （1.6 ± 0.2） and （1.3 ±0.3） in the control group; the static and dynamic sedation rates were 100.0% and 100.0% in the observation group and were 58.3% and 41.7% in the the control group; the sufentanil dosage was （41.47 ±3.26）μg in the observation group and was （58.32±3.79） μg in the control group; the rate of remedial analgesia was 0.0% in the observation group and was 37.5% in the control group; the incidence of postoperative adverse reactions was 0.0% in the observation group and was 12.5% in the control group; there were statistical differences between these two groups （all P 〈 0.05）. Conclusions Analgesia with dexmedetomidine and sufentanil after tangential excision of eschar and skin grafting in children with large area of burn wound is effective and can reduce adverse reactions.

关 键 词：右美托咪定 削痂植皮术 舒芬太尼 

分 类 号：R726.1[医药卫生—儿科]