甲钴胺联合前列地尔治疗DPN疗效及对血液流变学的影响  

Effects of mecobalamine combined with alprostadil in treatment of DPN and impacts on blood rheology

作　　者：刘媛媛[1] 

机构地区：[1]延安大学咸阳医院血液内分泌科,陕西咸阳712000

出　　处：《西南国防医药》2017年第4期346-348,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨甲钴胺联合前列地尔治疗糖尿病周围神经病变(DPN)的疗效及对血液流变学的影响。方法以医院收治的144例DPN患者作为研究对象,根据入院单双号顺序依次纳入观察组及对照组各72例。在综合治疗的基础上,对照组加用甲钴胺治疗,观察组则加用甲钴胺联合前列地尔治疗,观察比较两组临床疗效、神经电生理指标和血液流变学指标、不良反应以及生活质量的变化。结果观察组的总有效率虽高于对照组,但差异无统计学意义(94.44%vs 86.11%,P>0.05)。治疗后,两组神经电生理、血液流变学指标及生活质量均得到明显改善,且观察组优于对照组(P<0.05)。观察组不良反应发生率与对照组比较无统计学差异(13.89%vs 6.94%,P>0.05)。结论甲钴胺联合前列地尔治疗DPN疗效好,可改善患者神经电生理和血液流变学指标,提高患者生活质量,值得临床推广。Objective To explore the effects of mecobalamine combined with alprostadil in the treatment of diabetic peripheral neuropathy （DPN） and the impacts on blood rheology. Methods total of 144 DPN patients admitted to our hospital were selected and divided into an observation group and a control group （n=72, respectively） according to the odd and even serial number of admission. On the basis of comprehensive treatment, the control group was further treated with mecobalamine and the observation group with mecobalamine combined with alprostadil. The changes of clinical efficacy, neurological and physiological parameters and hemorheological parameters, adverse reactions and quality of life between the two groups were compared, Results Even though the ORR in the observation group was higher than that in the control group, there was no statistically significant difference （94.44% vs 86.11%; P 〉 0.05）. After the treatment, the neural electrophysiology, blood rheology indicators and quality of life in the two groups were improved, and those in the observation group were better than those in the control group （P 〈 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （13.89% vs 6.94%, P 〉 0.05）. Conclusion The combination of mecobalamine with alprostadil has good effects on the treatment of DPN, can improve patients＂ neural electrophysiological and hemorheological indexes and the quality of life, and is worthy of clinical promotion.

关 键 词：糖尿病 周围神经病变 甲钴胺 前列地尔 神经电生理 血液流变学 

分 类 号：R587.1[医药卫生—内分泌]