去白细胞血液成分降低输血不良反应效果评价  

Evaluation of leukocyte-depleted blood components on reducing adverse events due to blood transfusions

作　　者：谢进荣 陈静 罗艳 姚泽婷 

机构地区：[1]文山州中心血站,云南文山663000

出　　处：《中国输血杂志》2017年第2期192-194,共3页Chinese Journal of Blood Transfusion

基　　金：文山州学科带头人培养对象项目支持(文科创人培办发〔2015〕1号)

摘　　要：目的评价输注去白细胞血液成分降低非溶血性发热反应和过敏反应发生率的实际效果。方法回顾本站2011-2015年度发给1家医疗机构临床输注合格血液成分共计70 981袋,其中:未经去白细胞的血液成分22094袋,经去除白细胞的血液成分48 887袋,根据回报《输血不良反应报告表》统计输血反应情况,对比分析两组输血反应发生率。结果去白组血小板、血浆、红细胞非溶血性发热反应发生率分别为0.19%、0.02%、0.06%,未去白组分别为2.25%、0.07%、0.43%,两组间非溶血性发热反应发生率比较有显著性差异(P<0.05);去白组血小板、血浆、红细胞、冷沉淀过敏反应发生率分别为1.26%、0.57%、0.09%及0.09%,未去白组分别为3.60%、0.89%、0.46%、0.40%,两组间过敏反应发生率比较均具有显著性差异(P<0.05)。结论去白血液成分能降低非溶血性发热反应发生率及过敏反应发生率。Objective To evaluate the effectiveness of transfusion of leukocyte-depleted blood components to reduce the incidence of febrile non-hemolytic reactions and allergic reactions. Methods According to record,a total of 70 981 bags qualified blood components were sent to a medical institution from January 1st,2011 to December 30 th,2015. Among these bags,22 094 bags of blood still contained white blood cells and were known as control group. While leukocytes were depleted in the rest of 48 887 bags,they were known as leukocyte depleted group. According to the adverse transfusion reaction report from statistics on transfusion reactions,the incidence of blood transfusion reaction was compared and analyzed between those two groups. Results For leukocyte-depleted group,the incidence of febrile non-hemolytic reaction was 0. 19%,0. 02%,and 0. 06% in platelet,plasma and red cell,respectively. The figures were 2. 25%,0. 07% and 0. 43% in control groups.The difference was statistically significant（ P〈0. 05）. For leukocyte-depleted group,the incidence of allergic reactions was1. 26%,0. 57%,0. 09% and 0. 09% in platelet,plasma,red cell and cryo-precipitated anti-hemophilic factor. For the control group,the figures were 3. 60%,0. 89%,0. 46%,and 0. 40%,respectively. The difference was statistically significant（ P〈0. 05）. Conclusion The leukocyte-depleted blood components can reduce the incidence of non febrile non-hemolytic reactions and allergic reactions.

关 键 词：白细胞去除 非溶血性发热反应 过敏反应 

分 类 号：R457.13[医药卫生—治疗学]