身痛逐瘀汤对DOMS模型大鼠骨骼肌微损伤和炎症因子的影响  

Effect of Shentong Zhuyu decoction on skeletal muscle micro-injury and inflammatory factors of DOMS rats model

作　　者：冯宇[1] 杨明会[1] 窦永起[1] 李绍旦[1] 张印[1] 王瑛[1,2] 蒲香蓉[1] 

机构地区：[1]中国人民解放军总医院中医内科,北京100853 [2]中国人民解放军93424部队

出　　处：《环球中医药》2017年第4期416-418,共3页Global Traditional Chinese Medicine

摘　　要：目的探讨身痛逐瘀汤治疗延迟性肌肉酸痛症(delayed onset muscle soreness,DOMS)的作用机理。方法将81只雄性SD大鼠按照随机原则分为运动模型组、西药对照组、中药实验组,每组27只。各组大鼠均进行力竭游泳训练,负重为大鼠体质量的3%。西药对照组给予维生素C片及维生素E软胶囊,中药实验组给予身痛逐瘀汤治疗。观察各组大鼠血清骨骼肌微损伤指标和炎症因子变化。结果中药实验组DOMS大鼠血清肌酸激酶值在24、72小时显著低于运动模型组及西药对照组;乳酸脱氢酶值在24、48、72小时显著低于运动模型组,其中24、48小时显著低于西药对照组;前列腺素E_2(prostaglandin E_2,PGE_2)值在24、72小时显著低于运动模型组。结论身痛逐瘀汤可以降低DOMS模型大鼠骨骼肌微损伤程度,并抑制炎症因子的释放。Objective To explore the therapy mechanism of Shentong Zhuyu decoction on DOMS. Methods 81 male SD rats were randomly divided into control group, western medicine control group and Chinese medicine treatment group. All rats were given exhausting swimming train with a load of 3% body weight. The western medicine control group was treated with vitamin C tablets and vitamin E soft capsules, the Chinese medicine treatment group was treated with Shentong Zhuyu decoction. The changes of CK, LDH, PGE2 were observed. Results The level of CK in Chinese medicine treatment group was obviously lower than that of control group, western medicine control group in 24 hours and 72 hours. The level of LDH in Chinese medicine treatment group was obviously lower than that of control group, western medicine control group in 24 hours and 48 hours. The level of PGE2 in Chinese medicine treatment group was obviously lower than that of control group in 24 hours and 72 hours. Conclusion Shentong Zhuyu decoction can lower the level of skeletal muscle micro-injury and inhibit the release of inflammatory factors.

关 键 词：身痛逐瘀汤 延迟性肌肉酸痛症 骨骼肌微损伤 炎症因子 

分 类 号：R285.5[医药卫生—中药学]