189例帕金森病直立性低血压发生率及相关危险因素临床分析  

Clinical Analysis of the Prevalence of Orthostatic Hypotension and Related Risk Factors in 189 Patients with Parkinson's Disease

作　　者：赵然[1] 田田[1] 籍炀飞[1] 胡文涛[1] 刘希[1] 杨勤[1] 卢宏[1] 

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052

出　　处：《中风与神经疾病杂志》2017年第3期242-246,共5页Journal of Apoplexy and Nervous Diseases

摘　　要：目的调查帕金森病(PD)患者直立性低血压(OH)的发生率,并进一步探讨OH的相关危险因素。方法对189例PD患者(PD组)及156例健康志愿者(对照组)进行清晨醒后卧立位血压的测量,采用自主神经症状量表(SCOPA-AUT)进行自主神经功能评估,对PD患者OH发生率及相关危险因素进行统计学分析。结果 PD组SCOPA-AUT评分明显高于对照组(P<0.01);PD组清晨醒后卧位收缩压、舒张压均高于对照组(P<0.05),PD组立位收缩压较卧位明显下降(P<0.01);PD组OH的发生率为31.75%,明显高于对照组的12.18%(P<0.01);PD组OH的发生与年龄、抗帕金森病药物的服用剂量正相关(P<0.01)。结论 PD患者存在明显的自主神经功能障碍;PD患者清晨醒后立位收缩压明显下降;PD患者OH的发生率较高;高龄、大剂量的抗帕金森药物是PD患者发生OH的危险因素。Objective To investigate the prevalence of orthostatic hypotension（ OH） in patients with Parkinson＇s disease（ PD） and further explore the related risk factors. Methods The blood pressure（ BP） both decub and standing when woke up in the morning were measured in 189 PD patients（ PD group） and 156 healthy controls（ control group）,all subjects were assessed by the Scale for Outcomes in PD for Autonomic Symptoms（ SCOPA-AUT） to judge their autonomic function,analysising the prevalence of OH and the related risk factors in PD group. Results The score of SCOPA-AUT in PD group was significantly higher than control group（ P〈0. 01）; When woke up in the morning,the decub systolic blood pressure（ SBP） and the decub diastolic blood pressure（ DBP） of PD group were higher than control group（ P〈0. 05）,compared with the decub SBP,the standing SBP significantly decreased in PD group（ P〈0. 01）; The prevalence of OH in PD group was31. 75%,which was significantly higher than control group（ P〈0. 01）; There were significant correlations between the prevalence of OH in PD and the age,the dose of anti-Parkinson drugs（ P〈0. 01）. Conclusion Patients with PD had obvious autonomic dysfunction; When woke up in the morning,compared with the decub SBP,the standing SBP significantly decreased in patients with PD; Patients with PD had a higher prevalence of OH; Older,larger dose of of anti-Parkinson drugs were risk factors for the prevalence of OH in patients with PD.

关 键 词：帕金森病 直立性低血压 自主神经功能障碍 发生率 危险因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]