干扰素γ调节肝细胞周期及细胞凋亡的研究进展  

Research progress of IFN-γ regulating the cell cycle and apoptosis of hepatocytes

作　　者：李晓婷[1] 宋佰芬[2] 王歆桐 崔玉东[1] 

机构地区：[1]黑龙江八一农垦大学动物科学技术学院,黑龙江大庆163319 [2]黑龙江八一农垦大学生命科学技术学院,黑龙江大庆163319

出　　处：《黑龙江畜牧兽医》2017年第4期67-69,73,共4页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学青年科学基金项目(31101799)

摘　　要：干扰素γ(IFN-γ)是具有广谱抗病毒、免疫调节和抗增殖作用的炎性细胞因子。在肝脏中,IFN-γ可以引起肝细胞的细胞周期阻滞和细胞凋亡。这些生理过程主要是对肝脏起到保护作用,但是在长期的肝病中就可能会导致致癌基因的突变。文章就IFN-γ的结构特点、受体及信号通路,以及对肝细胞周期及凋亡的影响进行了综述。Interferon gamma （IFN -γ） is an inflammatory cytokine with broad - spectrum antiviral, immunomodulatory and antiproliferative effects. IFN - γ in the liver can cause the cell cycle arrest and apoptosis of hepatocytes. These physiological processes are primarily responsible for liver protection, but they may lead to oncogenic mutations in the long - term liver disease. This paper reviews the structural features, receptors and signaling pathway of IFN - γ as well as the influence of IFN -γ on the cell cycle and apoptosis of hepatocytes.

关 键 词：干扰素γ(IFN-γ) 肝细胞 细胞周期 细胞凋亡 STAT1 

分 类 号：Q854.563[生物学]