病毒性心肌炎感染患者干扰素-γ和白细胞介素-10的表达及药物干预效果研究  

Expression of IFN-γ and IL-10 and the effect of drug intervention for infected patients with viral myocarditis

作　　者：张晶晶[1] 杨瑞[1] 宋魏 黄捷[1] 宋昆鹏[1] 秦立[1] 韩凌[1] ZHANG Jing-jing YANG Rui SONG Wei HUANG Jie SONG Kun-peng QIN Li HAN Ling(Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, Chin)

机构地区：[1]郑州大学附属郑州中心医院心血管内科二病区,河南郑州450000 [2]郑州大学附属肿瘤医院病理科,河南郑州450008

出　　处：《中华医院感染学杂志》2017年第7期1504-1506,1513,共4页Chinese Journal of Nosocomiology

基　　金：河南省教育厅自然科学研究计划项目(2013A371148)

摘　　要：目的探究病毒性心肌炎感染患者干扰素-γ(IFN-γ)和白细胞介素-10(IL-10)等相关指标的变化情况及给予患者药物干预的临床效果,为临床实践提供指导和借鉴。方法选取2012-2013年医院收治的病毒性心肌炎患者80例,根据患者的病情分成急性期组36例和迁延期组44例,同期选取医院体检的健康人群33名为对照组,比较3组受试者临床指标。结果对照组IFN-γ显著低于急性期组和迁延期组,急性期组高于迁延期组;对照组IL-10显著高于急性期组和迁延期组,急性期组低于迁延期组;两组患者在给予抗柯注射液进行药物干预后,IFN-γ与治疗前相比均显著降低,IL-10与治疗前相比均显著升高。结论患者感染病毒性心肌炎后,其体内IFN-γ水平会显著升高,IL-10水平会显著降低,给予抗柯注射液干预后患者IFN-γ和IL-10水平均可得到显著改善。OBJECTIVE To explore the changes of IFN-γ and IL-10 and the effect of drug intervention for infected patients with viral myocarditis, so as to provide guidance and reference for clinical practice. METHODS A total of 80 patients with viral myocarditis from Dec. 2012 to Dec. 2013 were chosen. According to the patientrs condition, the patients were divided into acute phase group （36 cases） and protracted group （44 cases）, and 33 healthy peo- ple in our hospital were set as control group. The clinical indexes of the three groups were compared. RESULTS The IFN-γ of control group was significantly lower than that of acute phase group and protracted group, and acute phase group was significantly higher than that of protracted group. The IL-10 of control group was significantly higher than that of acute phase group and protracted group, and acute phase group was lower than that of protrac- ted group. After given anti-Ke injection drug intervention for the two groups, IFN-γ levels were significantly re- duced after treatment, and the IL-10 levels of the two groups after treatment were significantly increased. CONCLUSION After infected with viral myocarditis, the IFN-γ level in vivo will significantly increase, and the IL- 10 level will significantly reduce, and the IFN-γ and IL-10 levels can be significantly improved after given anti-Ke injection intervention.

关 键 词：病毒性心肌炎 IFN-Γ IL-10 药物干预 

分 类 号：R542.21[医药卫生—心血管疾病]