再生障碍性贫血患者血清VEGF、EGF、EPO、TPO及氧化应激的变化  

Changes of serum VEGF,EGF,EPO,TPO and oxidative stress of patients with aplastic anemia

作　　者：胡依民 李尚珠 

机构地区：[1]中国医学科学院血液病医院综合诊疗中心内科,天津300020

出　　处：《实用临床医药杂志》2017年第5期57-60,共4页Journal of Clinical Medicine in Practice

基　　金：国家科技支撑计划项目(2016BAI52B03)

摘　　要：目的研究及探讨再生障碍性贫血患者血清VEGF、EGF、EPO、TPO及氧化应激的变化。方法选取54例再生障碍性贫血患者为观察组,54名健康同龄人员为对照组,将2组研究对象的血清VEGF、EGF、EPO、TPO、酶抗氧化指标及非酶抗氧化指标进行检测及比较,比较观察组中不同Camitta分型与分类患者的血清VEGF、EGF、EPO、TPO、酶抗氧化指标及非酶抗氧化指标,并以Logistic分析上述血清指标与再生障碍性贫血患者的关系。结果观察组的血清VEGF及EGF水平均显著低于对照组,而血清EPO及TPO水平均显著高于对照组,血清酶抗氧化指标中的TAC、SOD及CAT均显著低于对照组,血清MDA则显著高于对照组,血清非酶抗氧化指标中的MT、GSH、Zn及Se均显著低于对照组,血清Cu则显著高于对照组。观察组中不同Camitta分型患者的血清VEGF、EGF、EPO、TPO、酶抗氧化指标及非酶抗氧化指标水平也存在显著差异。经Logistic分析显示,上述血清指标均与再生障碍性贫血有密切的关系(P<0.05)。结论再生障碍性贫血患者的血清VEGF、EGF、EPO、TPO及氧化应激指标呈现明显异常的状态,且上述检测指标均与本病有密切的关系。Objective To study and investigate the changes of serum VEGF,EGF,EPO,TPO and oxidative stress of patients with aplastic anemia.Methods A total of 54 patients with aplastic anemia were selected as observation group,and 54 healthy people were selected as control group.The serum VEGF,EGF,EPO,TPO,enzymatic antioxidant indexes and non-enzymatic antioxidant indexes of two groups were detected and compared,and the serum VEGF,EGF,EPO,TPO,enzymatic antioxidant indexes and non-enzymatic antioxidant indexes were compared in patients with different Camitta types and classifications in the observation group.The relationship between those serum indexes and patients with aplastic anemia were analyzed by the Logistic analysis.Results The serum VEGF and EGF levels of observation group were significantly lower than those of control group,while the serum EPO and TPO levels were significantly higher than those of control group,the serum enzymatic antioxidant indexes including TAC,SOD and CAT of observation group were significantly lower than those of control group,serum MDA was significantly higher than that of control group,serum non-enzymatic antioxidant indexes including MT,GSH,Zn and Se were significantly lower than those of control group,serum Cu was significantly higher than that of control group,and the serum VEGF,EGF,EPO,TPO,enzymatic antioxidant indexes and non-enzymatic antioxidant indexes of observation group with different Camitta types all had significant differences,and those serum indexes all had close relationship with the aplastic anemia（P〈0.05）.Conclusion The serum VEGF,EGF,EPO,TPO and oxidative stress of patients with aplastic anemia are in abnormal state,and these indexes all have close relationship with the disease.

关 键 词：再生障碍性贫血 血清 VEGF EGF EPO TPO 氧化应激 

分 类 号：R556.5[医药卫生—血液循环系统疾病]