黄体期和卵泡期促排卵在卵巢低反应患者中的应用  

Application of promoting ovulation at luteal phase and follicular phase in ovarian hyporesponsive patients

作　　者：刘林丽[1] 齐碧如[1] 黄勉[1] 林舟[1] 刘欣茹[1] 林珺[1] LIU Linli QI Biru HUANG Mian LIN Zhou LIU Xinru LIN Jun(Department of Obstetrics and Gynecology, Fujian Medical University Affiliated Fuzhou First Hospital, Fuzhou 350000, Chin)

机构地区：[1]福建医科大学附属福州市第一医院妇产科,福建福州350000

出　　处：《中国现代医生》2017年第8期62-65,69,共5页China Modern Doctor

基　　金：福建省福州市科技局基金项目(2016-S-122-2)

摘　　要：目的观察及比较不同时期促排卵方案对POR患者的临床结局。方法回顾性分析37例卵巢低反应患者第1周期行卵泡期促排卵失败后,第2周期改行黄体期促排卵,与109例行卵泡期微刺激促排卵患者对比,比较两组促排卵方案的胚胎发育及妊娠结局情况。结果黄体期促排卵组共获卵120枚,卵泡期促排卵组获卵379枚,两组平均获卵数[(4.37±1.07)vs(4.79±1.12)]无统计学差异(P>0.05)。但黄体期促排卵组的正常受精率[(93.3%)vs(73.4%)]、优质胚胎率[(88.7%)vs(78.7%)]及临床妊娠率[(27.0%)vs(13.4%)]均显著高于卵泡期促排卵组,差异有统计学意义(P<0.05)。结论黄体期促排卵是可行的,不失为卵巢反应低下患者促排卵的新思路。Objective To observe and compare the clinical outcome of ovariectomized patients in different periods. Methods 37 poor ovarian response patients were retrospectively analyzed. The patients switched to undergo the promo- tion ovulation at luteal phase in the second cycle after the failure of promoting ovulation at follicular phase. And the patients were compared with 109 cases undergoing micro-stimulation to promote ovulation. The embryo development and pregnancy outcome between the two ovulation promotion programs were compared. Results There were 120 ova in the luteal-phase ovulation promotion group and 379 ova in the follicular-period ovulation promotion group. There was no statistical difference in the average number of obtained ova between the two groups[（4.37±1.07） vs （4.79±1.12）]. Nor mal fertilization rate[（93.3%）vs.（73.4%）], good quality embryo rate[（88.7%） vs （78.7%）land clinical pregnancy rate [（27.0%） vs （13.4%）] in the luteal-phase ovulation promotion group was higher than that of the follicular period ovu- lation promotion group, respectively. And the differences were statistically significant （P〈0.05）. Conclusion Promoting ovulation at luteal-phase is feasible, which is a new idea for ovulation induction in patients with low ovarian response.

关 键 词：黄体期促排卵 卵泡期促排卵 微刺激 卵巢低反应 妊娠结局 

分 类 号：R711.75[医药卫生—妇产科学]