双、四咪唑鎓环番对核苷、核苷酸的选择性识别性能  

The Selective Recognition Activity of Bis-imidzolium and Tetra-imidzolium Cyclophane for Nucleoside and Nucleotide

作　　者：潘云芹 蒋宗林[1] 唐军[1] 李宇飞[1] 任涛[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637009

出　　处：《西华师范大学学报（自然科学版）》2017年第1期52-56,共5页Journal of China West Normal University(Natural Sciences)

基　　金：四川省科技厅科技支撑项目(2015SZ0204);四川省教育厅自然科学基金重点项目(13ZA0009)

摘　　要：报道了四种咪唑鎓环番的合成及其结构表征。采用荧光光谱法研究了环番主体对客体(核苷、核苷酸)的选择性识别。结果表明:空腔较大的四咪唑鎓环番5、7对核苷、核苷酸的识别性好,空腔较小的双咪唑鎓环番对I-有很高的识别活性。核磁滴定实验研究发现5与GTP、D-核糖的识别作用的主要部位可能来自GTP分子中糖单元结构。This paper talks about the synthesis and structural characterization of four kinds of imidazolium com- pounds. The method of fluorescent spectra is adopted to study the selective recognition of Cyclophane for guest mole- cule （nucleoside,nucleotide）. The results show that the tetra- imidazolium 5,7 have a good recognition of nucleoside and nucleotide whereas bis-imidazolium is better at recognizing I- ion. Through 1HNMR titration study of cyclophane 5 with GTP and D-ribose,it is found that the host-guest recognition site is possibly based on the sugar unit of GTP.

关 键 词：咪唑鎓 荧光光谱 核磁滴定 识别 

分 类 号：O626.23[理学—有机化学]