Box-Behnken效应面法优选川贝清咽含片辅料  

Excipients Optimization of Chuanbei Qingyan Buccal Tablets with Box-Behnken Response Surface Method

作　　者：马旻新 吴诗惠[1] 韩丽[1] 朱宁[1,2] 杨安东[2] 

机构地区：[1]成都中医药大学药学院、中药材标准化教育部重点实验室、四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地,四川成都611137 [2]四川省中医药科学院,四川成都610041

出　　处：《四川中医》2017年第3期60-62,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:优选川贝清咽含片辅料。方法:以蛋白质粉(大豆分离蛋白:乳清蛋白=4:1,m/m)、薄荷脑、阿斯巴甜用量为自变量,以含片口感、硬度、崩解时限为因变量,通过对自变量各水平多元线性回归及二项式拟合,采用Box-Behnken效应面法优选川贝清咽含片辅料。结果:优选的最佳工艺条件为蛋白质粉(大豆分离蛋白∶乳清蛋白=4∶1,m/m)为3.81g/16片,阿斯巴甜为68.77mg/16片,薄荷脑为6.82mg/16片。结论:Box-Behnken效应面法用于川贝清咽含片辅料的优化是可行的,数学模型的预测值与试验观察值相符。Objective ： Optimizing the excipients of Chuanbei Qingyan Buccal Tablets. Methods ： With protein powder （ soy protein isolated, whey protein = 4： 1, m/m）, menthol, dosage of aspartame as independent variables, lozenges, hardness, dis- integration time limit as the dependent variable, the levels of the independent variables of multivariate linear regression and the bi- nomial fitting, the Box-Behnken response surface method optimization fritillary bulb throat lozenges accessories. Results： Selec- ting the best technological conditions for protein powder （ = 4：1 soybean separation protein, whey protein, m/m） was 4. 36g/16 slices, aspartame is 68.77 mg/16 slices, menthol was 6. 82 mg/16 slices. Conclusion： Box-Behnken response surface method is used to clear throat lozenges fritillary bulb accessories optimization is feasible, the mathematical model of the predicted values are in conformity with experimental observations.

关 键 词：川贝清咽含片 BOX-BEHNKEN效应面法 制剂辅料 

分 类 号：R284.1[医药卫生—中药学]