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作 者:戴维佳[1] 庞红[1] 江燕[1] 刘小祥[1] 施玮[1] 李智[2]
机构地区:[1]上海市长宁区疾病预防控制中心,上海200051 [2]上海市疾病预防控制中心,上海200336
出 处:《上海预防医学》2017年第3期194-196,203,共4页Shanghai Journal of Preventive Medicine
摘 要:目的分析上海市长宁区适龄儿童在接种1剂水痘疫苗1年后,再次接种1剂国产水痘减毒活疫苗(水痘疫苗)的血清抗体水平变化情况。方法以长宁区曾经接种过1剂水痘疫苗的1~3岁儿童为观察对象,共计入组206人。间隔1年对观察对象接种第2剂次水痘疫苗,于接种疫苗前和接种后35~42 d采集静脉血,用膜免疫荧光法(FAMA)进行血清水痘抗体水平检测,比较第2剂水痘疫苗接种前后抗体水平的差异。结果比较观察对象在接种第2剂水痘疫苗前后的血清水痘抗体滴度情况,免前的抗体几何平均滴度(GMT)为1∶11.90,免后的GMT为1∶71.04,后者的抗体水平明显高于前者,差异有统计学意义(t=18.1,P<0.01)。抗体增长≥4倍者比例为82.52%。结论间隔1年后接种第2剂水痘疫苗能有效提高受种者血液中的水痘抗体滴度。Objective To analyze the changes of serum antibody levels of children in Changning District of Shanghai City, who received the second dose of varicella vaccine at one year after the first dose thereof. Methods A total of 206 children aged at 1 to 3 years in Changning District who had received one dose of varicella vaccine were included as objects of observation in the observation group. They received the second dose of varicella vaccine at one year after the first dose thereof. Their venous blood was collected before the second dose thereof as well as and at 35 to 42 days thereafter, and the varicella antibody level was tested through Fluorescent Antibody to Membrane Antigen (FAMA) assay so as to compare the difference between the antibody level before the second dose of varicella vaccine and that thereafter. Results The varicella-zoster virus(VZV) antibody titers of the blood serum before and after the second dose of varicella vaccine for the objects of observation were compared. The geometric mean titers(GMT) of the antibody before and after the second dose of varicella vaccine were 1 : 11.90 and 1 : 71.04, respectively, with the antibody level of the latter significantly higher than that of the former { t = 18.1, P 〈0. 01) , which showed significant difference between the two. The objects of observation whose antibody levels increased to over 4 times their original antibody levels occupied 82.52% of the total objects of obervation. Conclusion The second dose of varicella vaccine received at one year after the first dose thereof can effectively improve the VZV antibody titer in the blood serum of immunization recipients.
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