急性冠脉综合征患者血清miRNA-208与血小板功能的关系  

Relationship between serum miRNA-208 and platelet function in patients with acute coronary syndrome

作　　者：李恩[1] 汪涛[2] 张丽华[1] 简立国[1] 孙利强[1] 牛少辉[1] 

机构地区：[1]郑州大学第二附属医院心血管内科,郑州450014 [2]郑州大学第二附属医院干部病房,郑州450014

出　　处：《郑州大学学报（医学版）》2017年第2期188-190,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：郑州市普通科技攻关计划项目141PPTGG453;河南省高等学校重点科研项目15A320019

摘　　要：目的:探讨急性冠脉综合征(ACS)患者血清miRNA-208与血小板功能的关系。方法:选取2014年1月至2015年9月郑州大学第二附属医院收治的ACS患者60例(ACS组)和非ACS患者20例(对照组),根据诊断结果将ACS组进一步分为心肌梗死组(n=32)和不稳定心绞痛组(n=28)。入院即刻对3组患者进行静脉血液采集,测定血小板计数(PLT)、血小板分布宽度(PDW)及平均血小板体积(MPV);利用实时荧光定量PCR法测定血清miRNA-208。结果:与对照组比较,心肌梗死组和不稳定心绞痛组血清miRNA-208、PDW、MPV升高,差异有统计学意义(P<0.05)。与不稳定心绞痛组比较,心肌梗死组血清miRNA-208、PDW、MPV升高,差异有统计学意义(P<0.05)。ACS患者血清miRNA-208与PDW和MPV呈正相关(r=0.828、0.766,P<0.05)。结论:ACS患者血清miRNA-208与血小板活化密切相关,miRNA-208参与了血小板活化的调控。Aim： To investigate the relationship between serum miRNA-208 and platelet function in patients with acute coronary syndrome（ ACS）. Methods： A total of 60 cases of ACS（ ACS group） and 20 cases of non-ACS（ control group）were collected,and the ACS group was further allocated into myocardial infarction group（ AMI group,n = 32） and unstable angina pectoris group（ UA group,n = 28）. Platelet（ PLT）,platelet distribution width（ PDW） and mean platelet volume（ MPV） were measured. The serum miRNA-208 was measured by real-time fluorescence quantitative PCR method. Results： Compared with control group,the serum level of miRNA-208,PDW and MPV were significantly higher in the AMI group and the UA group（ P〈0. 05）. Compared with the UA group,the serum level of miRNA-208,PDW,MPV were significantly higher in the AMI group（ P〈0. 05）. In patients with ACS,the serum level of miRNA-208 was correlated with PDW and MPV（ r = 0. 828,0. 766,P〈0. 05）. Conclusion： miRNA-208 is closely related to platelet activation and involves in the regulation of platelet activation in patients with ACS.

关 键 词：急性冠脉综合征 miRNA-208 血小板分布宽度 平均血小板体积 

分 类 号：R541.4[医药卫生—心血管疾病]