两个二[氧合-二(取代苯甲酸二丁基锡)]的微波溶剂热合成、晶体结构和体外抗癌活性  

Microwave-Solvothermal Syntheses,Crystal Structures and in Vitro Antitumor Activities of Two Bis[oxo-bis(aromatic carboxylato dibutyltin)]

作　　者：冯泳兰[1] 邝代治[1] 张复兴[1] 庾江喜[1] 蒋伍玖[1] 朱小明[1] 

机构地区：[1]功能金属有机材料湖南省普通高等学校重点实验室,衡阳师范学院化学与材料科学学院,衡阳421008

出　　处：《无机化学学报》2017年第4期589-594,共6页Chinese Journal of Inorganic Chemistry

基　　金：湖南省高校创新平台开放基金(No.16K011,14K014);湖南省自然科学基金(No.13JJ3112)资助项目

摘　　要：在微波甲醇溶剂热中,二丁基氧化锡分别与4-叔丁基苯甲酸和3-甲基-4-氨基苯甲酸反应,合成了具有μ3-O桥联的有机锡化合物[(μ_3-O)(n-Bu_2Sn)_2(O_2CR)_2]_2(R=4-(t-Bu)-C_6H_5(1),(3-Me-4-NH_2)-C_6H_4(2)),并对它们的组成和结构进行了表征,X射线晶体衍射表明,化合物1、2的中心具有Sn2O2四元环平面结构,锡与配基原子构成畸形三角双锥六面体。人体外抗肿瘤活性的初步研究表明,化合物1、2对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)均显示出比临床使用的顺铂还强的抗癌活性。Two di-n-butyltin compounds with μ3-O bridging the framework,[（μ3-O）（n-Bu2Sn）2（O2CR）2]2（R=4-（t-Bu）-C6H5 （1）, （3-Me-4-NH2）-C6H4 （2））, were obtained by microwave-assisted solvothermal reaction of di-n-butyltin oxide precursor with the aromatic acid in methanol environments, which have been structurally characterized by elemental analysis, IR and NMR （^1H, ^13C and ^119Sn） spectra and X-ray crystallography diffraction analyses. This compound was of a centrosymmetric dimer structure mode with a four-membered central endo-cyclic Sn2O2 unit in which the bridging oxygen atoms were tri-coordinated. Each bridging oxygen atom also connects with an exo-cyclic tin atom. The endo-cyclic and exo-cyclic tin atoms all were five-coordinated with distorted trigonal bipyramid geometry. The compounds 1 and 2 have strong anti-tumor activity in vitro.

关 键 词：有机锡化合物 微波溶剂热合成 体外抗肿瘤活性 

分 类 号：O614.432[理学—无机化学]