基于质子共振频率MR温度成像监控高强度聚焦超声治疗  

MR temperature mapping based on proton resonance frequency for monitoring high-intensity focused ultrasound therapy

作　　者：彭玉红[1] 李发琪[1] 

机构地区：[1]重庆医科大学生物医学工程学院省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室重庆市微无创医学协同创新中心,重庆400016

出　　处：《中国医学影像技术》2017年第4期612-615,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81127901、11574039、11274404)

摘　　要：高强度聚焦超声(HIFU)作为一种热消融疗法,在治疗过程中需有良好的监控和实时精确的测温技术以保证治疗的安全性和有效性。MR温度成像通过具有温度敏感的参数进行测温,如弛豫时间、质子共振频率(PRF)、扩散系数、磁化矢量转移等,无创且无辐射,并可实时三维成像。其中,由于质子共振频率(PRF)对温度具有良好的线性度,且与组织类型不相关。基于PRF的MR温度成像成为中高场强(≥1T)系统应用的首选,在低场强系统中也有应用。本文对PRF MR温度成像的基本原理及其在监控HIFU治疗方面的研究进展进行综述。As a kind of thermal ablation therapy, high-intensity focused ultrasound （HIFU） can achieve more satisfied safety and efficacy of the treatment with excellent monitoring and real-time accurate temperature measurement technology during the therapy. Temperature measurement is feasible with MRI based on temperature sensitive parameters, such as relaxation times, proton resonance frequency （PRF）, diffusion coefficient and magnetization transfer. MRI temperature measurement technique is noninvasive and non-ionizing radiation, and also capable for real-time three-dimensional imaging. Among these temperature sensitive parameters, PRF has excellent linearity of temperature. Moreover, PRF is independent of tissue type. PRF based phase mapping methods is the preferred choice for medium and high field strength （≥ 1T） applications. It is also used for low-field MR system. The rationale of MR temperature mapping and the progresses of MR temperature mapping for monitoring HIFU treatment based on PRF technology were reviewed in this article.

关 键 词：高强度聚焦超声消融术 磁共振温度成像 质子共振频率 

分 类 号：R445.1[医药卫生—影像医学与核医学] R445.2[医药卫生—诊断学]