Synthesis and Characterizations of 1,4-butanediol( BDO )-Regulated Poly( ε-caprolactone)(PCL) Waterborne Polyurethane with Controlled Biodegradability for Medical Applications  

作　　者：何源 陈咏梅 邢建伟 

机构地区：[1]State Key Laboratory for Strength and Vibration of Mechanical Structures,International Center for Applied Mechanics and School of Aerospace,Collaborative Innovation Center of Suzhou Nano Science and Technology,Xi’an Jiaotong University [2]School of Textiles and Materials,Xi’an Polytechnique University

出　　处：《Journal of Donghua University(English Edition)》2017年第1期89-94,共6页东华大学学报（英文版）

基　　金：National Natural Science Foundation of China(No.51173144);International Science&Technology Cooperation Program Supported by Ministry of Science and Technology of China and Shaanxi Province,China(No.2013KW14-02);Program for the Key Science and Technology Innovative Team of Shaanxi Province,China(No.2013KCT-05);China Postdoctoral Science Foundation(No.2014M562405);Natural Science Foundation of Shaanxi Province,China(No.2015JQ5137);Collaborative Innovation Center of Suzhou Nano Science and Technology,Suzhou Research Institute,China(No.BY2013036)

摘　　要：Waterborne polyurethane （ WBPU ） with controlled biodegradability and biocompatibility was synthesized by using poly （ε-caprolactone） （ PCL ） as the polyglycol, isophorone diisocyanate （IPDI） as the isocyanate, 2 acid （DMPA） as the chain extender and 1, 4-butanediol （BDO） as the hard-segment regulating agent. We found that BDO content significantly influenced mechanical properties, degradable performances and cyto-biocompatibility of PCL-WBPUs. Increasing the BDO content in PCL-WBPU enhanced its tensile strength and decreases strain. Enzymolysis and hydrolysis properties were also regulated by BDO content, but with different meechanisms. Cyto- biocompatibility was evaluated with ATDC5 cells. The results show that the biodegradability of PCL-WBPU is significantly determined by BDO content, which exerts a serious influence on its polymer structure, leading to resultant degradable properties.Waterborne polyurethane(WBPU)with controlled biodegradability and biocompatibility was synthesized by using poly(ε-caprolactone)(PCL)as the polyglycol,isophorone diisocyanate(IPDI)as the isocyanate,2,2-bishydroxymethylbutyric acid(DMPA)as the chain extender and 1,4-butanediol(BDO)as the hard-segment regulating agent.We found that BDO content significantlyinfluencedmechanicalproperties,degradable performances and cyto-biocompatibility of PCL-WBPUs.Increasing the BDO content in PCL-WBPU enhanced its tensile strength and decreases strain.Enzymolysis and hydrolysis properties were also regulated by BDO content,but with different mechanisms.Cytobiocompatibility was evaluated with ATDC5 cells.The results show that the biodegradability of PCL-WBPU is significantly determined by BDO content,which exerts a serious influence on its polymer structure,leading to resultant degradable properties.

关 键 词：waterborne polyurethane （ WBPU ） BIOCOMPATIBILITY biodegradabilitv pattern hydrolysis rate 

分 类 号：TQ323.8[化学工程—合成树脂塑料工业]