Ethosomes-Silk Fibroin/Polyvinyl Alcohol Composite Hydrogel Transdermal Drug Delivery System : Preparation and Characterization  

作　　者：杨兴兴 余凡 马琳琳 骆格杰 潘潇涵 林思 王红声 

机构地区：[1]College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China [2]Key Laboratory of Textile Science & Technology, Ministry of Education, Shanghai 201620, China [3]Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, Donghua University, Shanghai 201620, China

出　　处：《Journal of Donghua University(English Edition)》2017年第1期99-104,共6页东华大学学报（英文版）

基　　金：Natural Science Foundation of Shanghai,China(No.12ZR1400300);the Innovation Foundation of Donghua University,China(No.EG2015067);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry,China;“111 Project”Biomedical Textile Materials Science and Technology,China(No.B07024)

摘　　要：One key of constructing ideal transdermal drug delivery system(TDDS)is enhancing the percutaneous rate of drugs without sacrificing compatibility.Ethosomes(Eths)have excellent transdermal performance as well as good biocompatibility,and thus been widely used as drug carrier.Hydrogel has good 3-dimensional mesh structure which is convenience for drugs release and storage.In this study,Eths were introduced into silk fibroin(SF)/polyvinyl alcohol(PVA)composite hydrogel to construct a novel TDDS through a green process.The Ethsomes(Eths)-SF/PVA composite hydrogel TDDS showed good mechanical properties(stress:(0.236±0.032)MPa;strain:(65.74±2.45)%).Also,skin fibroblasts can grow and proliferate well on this TDDS,indicating that this material has a good cytocompatibility.Furthermore,with doxorubicin hydrochloride(Dox)as a model drug loaded in ethosomes,in vitro studies showed that this TDDS was able to transdermally release Dox efficiently.Our data suggested this novel system had a good potential for application in TDD,though further evaluative study still needed to carry out.One key of constructing ideal transdermal drug delivery system （TDDS） is enhancing the percutancons rate of drugs without sacrificing compatibility. Ethosomes （ Eths ） have excellent transdermal performance as well as good biocompatibility, and thus been widely used as drug carrier. Hydrogel has good 3-dimensional mesh structure which is convenience for drugs release and storage. In this study, Eths were introduced into silk fibroin （ SF）/polyvinyl alcohol （PVA） composite hydrogel to construct a novel TDDS through a green process. The Ethsomes （Eths） -SF/PVA composite hydrogel TDDS showed good mechanical properties （stress： （0.236±0.032） MPa; strain： （65.74±2.45）%）. Also, skin fibroblasts can grow and proliferate well on this TDDS, indicating that this material has a good cytocompatibility. Furthermore, with doxorubicin hydrochloride （Dox） as a model drug loaded in ethosomes, in vitro studies showed that this TDDS was able to-ansdermally release Dox efficiently. Our data suggested this novel system had a good potential for application in TDD, though further evaluative study still needed to carry out.

关 键 词：transdermal drug delivery system Ethosomes(Eths) silk fibroin HYDROGEL polyvinyl alcohol 

分 类 号：R318.08[医药卫生—生物医学工程]