Influence of Sorbitan Monooleate on Morphology and Drug Release Behavior of Emulsion Electrospinning Polycaprolactone Nanofibers  

作　　者：彭晓 丁辛 林刚 胡吉永 杨旭东 

机构地区：[1]Key Laboratory of Textile Science &Technology, Ministry of Education, Donghua University, Shanghai 201620, China [2]College of Textiles, Donghua University, Shanghai 201620, China

出　　处：《Journal of Donghua University(English Edition)》2017年第1期122-126,共5页东华大学学报（英文版）

基　　金：“111 Project” Biomedical Textile Materials Science and Technology,China(No.B07024)

摘　　要：Ultrafine polycaprolactone(PCL)fibers containing watersoluble drug tetracycline hydrochloride(Tet)were prepared by emulsion electrospinning.Sorbitan monooleate(Span80)was added as an essential additive to form stable water/oil emulsions and fabricate fibers with core-sheath structure.Different concentrations of Span80(0-40 g/L)were used to investigate the stability of emulsion and size of dispersed droplets.The scanning electron microscope(SEM)images indicated that the morphology of the fibers with Span80 were beaded-free with diameters of 200-400 nm,and Span80 enhanced the spinnability of electrospinning solution.The laser scanning confocal microscope(LSCM)images indicated that Tet was well encapsulated into the core region of the PCL fibers.The transmission electron microscope(TEM)image showed the formation of core-sheath structure.The loading efficiency(LE)and entrapment efficiency(EE)of Tet were calculated and release profiles in artificial saliva buffer solution(pH=6.8)were also analyzed.The results revealed that LE and EE of fibers with Span80decreased with the increase of its concentration.Fibers with coresheath structure had a longer effective release lifetime than without Span80.The increase of Span80 resulted in higher hydrophilicity of fibers and faster release rate of Tet.Ultrafine polycaprolactone （PCL） fibers containing watersoluble drug tetracycline hydrochloride （Tet） were prepared by emulsion electrospinning. Sorbitan monooleate （Span80） was added as an essential additive to form stable water/oil emulsions and fabricate fibers with core-sheath structure. Different concentrations of Span80 （0-40 g/L） were used to investigate the stability of emulsion and size of dispersed droplets. The scanning electron microscope （SEM） images indicated that the morphology of the fibers with Span80 were beaded-free with diameters of 200-400 nm, and Span80 enhanced the spinnability of electrospinulng solution. The laser scanning confocal microscope （ LSCM ） images indicated that Tet was well encapsulated into the core region of the PCL fibers. The transmission dectron microscope （TEM） image showed the formation of core-sheath structure. The loading efficiency （LE） and entrapment efficiency （EE） of Tet were calculated and release profiles in artificial saliva buffer solution （ pH = 6. 8 ） were also analyzed. The results revealed that LE and EE of fibers with Span80 decreased with the increase of its concentration. Fibers with coresheath structure had a longer effective release lifetime than without Span80. The increase of SpanSO resulted in higher hydrophilicity of fibers and faster rdeaso rate of Tet.

关 键 词：polycaprolactone(PCL) nanofibers emulsion electrospinning core-sheath structure SPAN80 drug release behavior 

分 类 号：TS101.4[轻工技术与工程—纺织工程]