Thermo-Responsive Electrospun Nanofibers from Poly( N-isopropylacrylamide )/Polyvinyl Pyrrolidone Blends  

作　　者：吕瑶 吴焕岭 李赫宇 潘琪霞 朱利民 

机构地区：[1]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University [2]Jiuzhou College of Pharmacy,Yancheng Institute of Industry Technology

出　　处：《Journal of Donghua University(English Edition)》2017年第1期152-158,共7页东华大学学报（英文版）

基　　金：Science and Technology Commission of Shanghai Municipality,China(No.16410723700);"111 Project"Biomedical Textile Materials Science and Technology,China(No.B07024);UK-China Joint Laboratory for Therapeutic Textiles Based at Donghua University

摘　　要：A novel nanofiber composite poly(N-isopropylacrylamide)(PNIPAAm)/polyvinyl pyrrolidone(PVP)was successfully prepared by electrospinning.Analogous medicated fibers loaded with ketoprofen(KET)as a model drug were prepared.X-ray diffraction(XRD)demonstrated that the drug was presented in the fibers with an amorphous form.Both scanning and transmission electron microscopy showed that the fibers had an even diameter and smooth surface,and no phase separation was observed.The KET loaded nanofibers did not affect the morphology of the fibers,and no drug aggregation was separated from the polymer fibers.Water contact angle measurements proved that the PNIPAAm/PVP fibers switched from hydrophilic to hydrophobic when the temperature increased the lower critical solution temperature of 32℃.In vitro drug release studies were also undertaken and the result indicated that the PNIPAAm/PVP blend nanofiber presented the properties of the two polymers,having temperature-sensitive systems with sustained release properties.In addition,MTT assay demonstrated that the nanofiber film was non-toxic and suitable for cell growth.Thus,the nanofiber can be used as thermoresponsive carriers for sustained release of poor water soluble drugs.A novel nanofiber composite poly（N-isopropylacrylamide） （ PNIPAAm ）/polyvinyl pyrrolidone （ PVP ） was successfully prepared by electrospinning. Analogous medicated fibers loaded with ketoprofen （KET） as a model drug were prepared. X-roy diffraction （XRD） demonstrated that the drug was presented in the fibers with an amorphous form. Both scanning and transmission electron microscopy showed that the fibers had an even diameter and smooth surface, and no phase separation was observed. The KET loaded nanofibers did not affect the morphology of the fibers, and no drug aggregation was separated from the polymer fibers. Water contact angle measurements proved that the PNIPAAm/PVP fibers switched from hydrophilic to hydrophobic when the temperature increased the lower critical solution temperature of 32 ℃. In vitro drug release studies were also undertaken and the result indicated that the PNIPAAm/PVP blend nanofiber presented the properties of the two polymers, having temperature-sensitive systems with sustained release properties. In addition, MTT assay demonstrated that the nanofiber film was non-toxic and suitable for cell growth. Thus, the nanofiber can be used as thermoresponsive carriers for sustained release of poor water soluble drugs.

关 键 词：poly(N-isopropylacrylamide)(PNIPAAm) polyvinyl pyrrolidone(PVP) ELECTROSPINNING drug release 

分 类 号：R944.4[医药卫生—药剂学]