肥胖与胆管癌相关性的Meta分析  

Correlation of obesity and cholangiocarcinoma:a Meta analysis

作　　者：李君山[1] 韩天洁[2] 聂晶[1] 宫健[1] 高新英[1] 井夫春[1] 王庆才[1] 

机构地区：[1]泰安市中心医院消化内一科,山东省271000 [2]泰安市中心医院血液内科,山东省271000

出　　处：《中华消化病与影像杂志（电子版）》2017年第2期60-65,共6页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的评估超重或肥胖和胆管癌发病之间的关系。方法:通过检索Pub Med、Cochrane、Embase、中国生物医学文献数据库(CBM),纳入研究肥胖与胆管癌发病风险的文章进行Meta分析。结果 16研究符合纳入标准,其中包括5个队列和11个病例对照研究。与正常体重相比,体重超重(合并OR:1.20,95%CI:1.07~1.34)、肥胖(合并OR:1.66,95%CI:1.31~2.11)和过重(合并OR:1.33,95%CI:1.18~1.49)与胆管癌发病均显著相关。漏斗图显示无发表偏倚的证据。结论:肥胖增加胆管癌的发病风险增加,还需要长期的队列研究进一步证实。Objective To assess the association between overweight or obesity and the incidence of cholangiocarcinoma. Methods Using PubMed, Cochrane, EMBase and CBM databases, studies were included if they reported cholangiocarcinoma with respect to obesity or overweight. Results Sixteen studies met the inclusion criteria, which included five cohort and eleven case-control studies. Compared with normal weight, being overweight （pooled 20,95% CI： 1. 07-1. 34） , obesity （ pooled 66,95% CI： 1.31-2. 11） , and excess body weight （ pooled OR： 1.33,95% CI： 1.18-1.49 ） were significantly associated with cholangiocarcinoma. The funnel plot revealed no evidence for publication bias. Conclusion Obesity is associated with the increased risk of cholangiocarcinoma, which needs to be confirmed by long-term cohort studies.

关 键 词：胆管肿瘤 超重 肥胖症 队列研究 病例对照研究 META分析 

分 类 号：R589.2[医药卫生—内分泌] R735.8[医药卫生—内科学]