高血压患者血压变异性与动脉僵硬度的相关性研究  

Study on the Correlation between Variability and Arterial Stiffness

作　　者：余强 李晨 陈曼君 刘伟红 李敏 王丹 王宏宇[1,2] 

机构地区：[1]北大医疗株洲恺德心血管病医院血管医学科,株洲412000 [2]北京大学首钢医院血管医学中心,北京100144

出　　处：《中国医药导刊》2017年第3期217-218,220,共3页Chinese Journal of Medicinal Guide

基　　金：北京市卫生局首都卫生发展科研专项(编号:首发2011-4026-02);项目名称:北京地区血管事件高危人群中血管病变早期检测系统的建立及其预测价值研究;2015年株洲市科技计划项目(无编号);项目名称:株洲地区高血压患者动脉僵硬度评价及其影响因素分析

摘　　要：目的:探讨高血压患者动脉僵硬度评价指枥-心踝血管指数(CAVI)与血压(BP)变异性(BPV)及其影响因素的相关性。方法:133例原发性高血压患者进行24h AMBP监测及动脉硬化CAVI监测,根据收缩压(SBP)变异性(SPV)分为三组:A组:SBPV<0%、B组:SBPV0%~10%和C组:SBPV 10%~20%。分析患者CAVI与BPV以及相关危险因素的关联性。结果:高血压患者CAVI与SPV及舒张压(DBP)变异性(DPV)呈显著负相关(P<0.05)。SPV<0%,CAVI随SPV绝对值增加而增加,SPV为0%~20%,随SPV绝对值增加而降低(P<0.05)。夜间平均指标(SBP、DBP、BP和脉压)组间差异显著(P<0.01)。相关性分析提示CAVI与血肌酐、血尿酸、NSP、DSP、N-MAP、24h平均指标(SBP、BP、脉压)分别呈显著相关性(P均<0.05)。多元线性回归分析提示年龄、体质量指数、夜间指标(脉压、日间脉压、SPV、DPV)是高血压患者动脉僵硬度的相对独立危险因素。结论:高血压患者BPV保持在10%~20%水平时动脉僵硬度最低,BPV<0%时动脉僵硬度最高,在0%~10%时居中。夜间BP及脉压水平是影响BPV的主要因素。Objective：To investigate the cardio ankle vascular index arterial stiffness in patients with hypertension index（CAVI） and blood pressure（BP） variability（BPV） and its influencing factors correlation.Methods：133 cases of patients with primary hypertension were monitored by 24 hAMBP and CAVI.According to the systolic blood pressure（SBP） variability（SPV）,groups were divided into three groups：groupA SBPV 0%,group B：SBPV 0%~ 10%and group C：SBPV 10%-20%.The correlation between CAVI and BPV and related risk factors were analyzed.Results：The CAVI and diastolic blood pressure（DBP） variability（DPV） was significantly negatively correlated with SPV in hypertensive patients（P〈0.05）.SPV 0%,CAVI increases with the absolute value of SPV,SPV is 0%-20%,then decreases with the absolute value of SPV（P〈0.05）.The difference was significant between the groups（P〈0.01） in the night time average（SBP,DBP,BP and pulse pressure）.Correlation analysis showed that CAVI was significantly correlated with serum creatinine,serum uric acid,NSP,DSP,N-MAP,24h（SBP,BP,pulse pressure）,respectively（P〈0.05）.Multivariate linear regression analysis showed that age,body mass index,index（nocturnal pulse pressure,daytime pulse pressure,SPV,DPV） is a relatively independent risk factors of arterial stiffness in hypertensive patients.Conclusion：Patients with hypertension BPV maintained at 10%-20%level of arterial stiffness is lowest,BPV 0%arterial stiffness is highest,at the center of 0%~ 10%.NocturnalBP and pulse pressure are the main factors that affect the BPV.

关 键 词：高血压 CAVI 血压变异性 动脉僵硬度 

分 类 号：R544.1[医药卫生—心血管疾病]