沉淀法与水热法合成载银羟基磷灰石及其抗菌性能  

Synthesis and Antibacterial Property of Silver Doped Hydroxyapatite by Precipitation and Hydrothermal Method

作　　者：邓城 漆小鹏[1] 李倩[1] 尹从岭[1] 杨辉[1] 

机构地区：[1]江西理工大学材料科学与工程学院,江西赣州341000

出　　处：《材料工程》2017年第4期113-120,共8页Journal of Materials Engineering

基　　金：江西理工大学科研基金重点课题资助项目(NSFJ2014-K10);国家自然科学基金资助项目(21301077)

摘　　要：采用沉淀法与水热法合成了纳米棒状载银羟基磷灰石(Ag-HA)颗粒。研究不同合成方法和载银量时Ag-HA晶体结构、形貌及抗菌性能。结果表明:水热法合成的Ag-HA长径比高、分散性好,产物结晶度高、晶粒尺寸大,晶胞参数更小。沉淀法70℃时,Ag-HA平均晶粒尺寸为(22.7±0.7)nm;水热法180℃时,平均晶粒尺寸为(50.7±0.9)nm。银的引入会增大产物晶粒尺寸及晶胞参数,当载银量为1.30%时,平均晶粒尺寸为(53.7±0.9)nm,晶胞参数a=0.9465nm,c=0.6970nm。产物与大肠杆菌(E.coli)和金黄色葡萄球菌(S.aureus)共培养后结果显示,Ag-HA对两种实验菌均表现出良好的杀菌性能,不同载银量Ag-HA在1,3,6,12,24h后的杀菌率均为100%。Nanorod Ag doped hydroxyapatites(Ag-HA)were synthesized by precipitation and hydrothermal method.Crystal structure,morphology and antibacterial property of prepared samples with silver contents prepared by different synthesis methods were investigated.The results show that Ag doped hydroxyapatites synthesized by hydrothermal method possess a higher length to diameter ratio,higher degree of crystallinity,better dispersion,larger grain size and smaller unit cell parameters.The average crystal size of prepared samples by precipitation method at 70℃ and hydrothermal method at 180℃ are(22.7±0.7)nm and(50.7±0.9)nm,respectively.In addition,adding silver into hydroxyapatite may increase grain size and unit cell parameters.When silver content is 1.30%,average grain size and unit cell parameters are(53.7±0.9)nm and a=0.9465 nm,c=0.6970 nm,respectively.Antibacterial test results indicate that Ag-HA exhibits good bactericidal property against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).The antibacterial rate is 100% when silver content varies after different hours(1,3,6,12,24h).

关 键 词：载银羟基磷灰石 沉淀法 水热法 晶体结构 抗菌性能 

分 类 号：TB34[一般工业技术—材料科学与工程]