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机构地区:[1]北京大学国际医院核医学科,北京102206 [2]北京大学第一医院核医学科,北京100034
出 处:《中国医学装备》2017年第4期21-24,共4页China Medical Equipment
基 金:国家重大科学仪器设备开发专项(2011YQ03011409)"基于多模态分子影像技术的新型肿瘤新生血管靶向显象剂及治疗药物研究";国家"十二五"支撑项目基金(2014BAA03B03)"~(99)Tc~m-RRL新型靶向肿瘤新生血管放射性药物的实验研究";天津市自然科学基金重点项目(16JCZDJC35100)"多模态金纳米探针提高非小细胞肺癌精准诊断的研究"
摘 要:如何研究一种能显著提高恶性肿瘤治疗增益比的方法,是目前癌症治疗领域必须解决的问题之一,而对于如何能有效治疗具有手术和放化疗禁忌证的恶性肿瘤患者是肿瘤治疗的难题。^(125)I粒子植入疗法适用于治疗有手术、外放射治疗和化疗禁忌证的患者。运用多模态影像引导,有助于组织密度影像靶区和生物靶区的界定,能够保证治疗的靶向性和适形性。应用放射剂量学优化的质量保证和质量控制(QA/QC)措施、应用治疗计划系统(TPS)制定方案并进行放射剂量学的优化、剂量—体积直方图(DVH)等评估TPS以及影像引导粒子植入,并进行实时位置验证、植入后剂量学验证、疗效判定和随访等方法,能够提高治疗的增益比和局部控制疗效,进而显著降低不良反应,对提高患者生存率和生存质量具有重要的临床意义。How to study a method that can significantly improve the therapeutic gain ratio of malignant tumor is one of the problems must be solved in the field of cancer therapy. However, how can effectively treat malignancy patients with contraindications of operation, radiotherapy and chemotherapy has been a difficult problem in cancer therapy. The 125I brachytherapy was suitable for malignancy patients with contraindications of operation, radiotherapy and chemotherapy. The guidance of multimodal imaging could contribute to the definitions of tissue density imaging target and biological target, and could ensure the targeting and conformity of treatment. Using the quality assurance and quality control measurements(QA/QC) optimized by radiation dosimetry; using therapy planning system(TPS) to make plan, and adopt optimizing radiation dosimetry and dose volume histogram(DVH) to evaluate TPS, and using image to guide particle implantation and adopt series of methods, such as real-time location verification, dosimetry verification post-implantation, therapy efficacy determination, follow-up and so on, to improve therapeutic gain ratio and partially control therapy efficacy, and then significantly reduce adverse reaction. All of these have important clinical value for increasing survival rate and quality of life.
关 键 词:放射性125I粒子 植入治疗 近距离治疗 多模态影像引导 放射剂量优化 治疗增益比
分 类 号:R817.8[医药卫生—影像医学与核医学]
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