慢性苯中毒31例患者治疗前后血液学分析  

Hematology analysis on 31 cases of chronic benzene poisoning before and after treatment

作　　者：张志敏[1,2] 张艳芳 李培茂[1,2] 王佃鹏 林大枫 王革非[1] 

机构地区：[1]汕头大学医学院微生物与免疫学教研室,广东汕头515031 [2]深圳市职业病防治院临床检验科,广东深圳518001

出　　处：《职业与健康》2017年第3期306-309,共4页Occupation and Health

基　　金：深圳市科技研发资金基础研究项目(JCYJ20140414110951757);深圳市科技研发资金基础研究项目(JCYJ20160429090813380)

摘　　要：目的探讨慢性苯中毒患者治疗前后的外周血常规、血细胞形态及骨髓象分类及形态特点。方法根据GBZ 68《职业性苯中毒的诊断》标准对患者分组,进行外周血常规及血细胞形态检查。选取材、涂片、染色好的骨髓片计数有核细胞200个,对其进行分类并观察细胞形态。结果与对照组比较,治疗前的轻、中、重度中毒组WBC、RBC、PLT计数及Hb含量均下降,差异有统计学意义(P<0.05)。与治疗前比较,治疗后的WBC、PLT计数及Hb的变化,差异无统计学意义(P>0.05)。治疗后外周血细胞形态与治疗前相比变化不大。治疗后骨髓增生程度、粒红细胞比值均主要集中在正常区间,不同中毒程度组间骨髓增生程度及粒红细胞比值,差异无统计学意义(P>0.05)。骨髓粒系及红系形态均无明显毒性改变。结论治疗前后外周血常规及血细胞形态变化不大,治疗后骨髓象有所改善。[Objective]To explore the conventional peripheral blood cells,blood cell morphology,bone marrow cell morphology classification and morphological in patients with chronic benzene poisoning before and after treatment. [Methods]The patients were grouped according to the criteria of Diagnosis of occupational benzene poisoning（GBZ68）,and the conventional peripheral blood examination and blood cell morphology test were performed. 200 bone marrow nucleated cells that were good selected,smeared and stained materials were classified,to observe the cell morphology. [Results]Before treatment,the white blood cell（WBC）count,red blood cell（RBC）count,platelet（PLT）count and hemoglobin（Hb）content in the mild,moderate and severe poisoning groups decreased as compared with the control group,and the differences were statistically significant（P〈0.05）. There were no statistically significant differences in WBC count,PLT count and Hb content between before and after treatment（P〉0.05）.No significant difference in peripheral blood cell morphology between before and after treatment was observed. After treatment,the degree of bone marrow and hyperplasia to RBC ratio mainly concentrated in the normal range. There were no statistically significant differences in the degree of bone marrow and hyperplasia to RBC ratio among the mild,moderate and severe poisoning groups（P〉0.05）. No significant toxicity change was observed in myeloid granulocyte and erythroid cells. [Conclusion]Before and after treatment,there are no significant changes in conventional peripheral blood cells and blood cells morphology before and after treatment. The bone marrow cell morphology has improved after treatment.

关 键 词：慢性苯中毒 治疗前 治疗后 外周血常规 骨髓象 

分 类 号：R135.13[医药卫生—劳动卫生]