邻苯二甲酸酯类暴露与人群肥胖关系的Meta分析  

Association between phthalate ester exposure and population obesity:A Meta-analysis

作　　者：徐缙[1] 陈怀基 许峰[1] 王琪[1] 张月竹[1] 刘洪泊 张天融 叶琳[1] XU Jin CHEN Huaiji XU Feng WANG Qi ZHANG Yuezhu LIU Hongbo ZHANG Tianrong YE Lin(Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学公共卫生学院劳动卫生与环境卫生学教研室,吉林长春130021

出　　处：《吉林大学学报（医学版）》2017年第2期306-310,共5页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(81573184)

摘　　要：目的:采用Meta分析系统评价邻苯二甲酸酯类暴露与人群肥胖的关系,为预防和控制人群肥胖的发生提供新思路。方法:全面检索PubMed、Web of Science、The Cochrane Library、Elsevier Science Direct、OVID等外文数据库和中国生物医学文献数据库、中国知网数据库、维普数据库、万方数据库等中文数据库,查找国内外关于邻苯二甲酸酯类暴露与人群肥胖关系的中英文文献。根据纳入标准和排除标准筛选文献,提取纳入文献的相关数据,采用RevMan 5.3软件进行Meta分析。结果:最终纳入文献6篇,样本量共1 259例。Meta分析,肥胖人群尿液中邻苯二甲酸单丁酯(MBP)是正常人群的4.1倍(95%CI:1.43~6.76);而2组人群血清中邻苯二甲酸二丁酯(DBP)、邻苯二甲酸二乙基己酯(DEHP)和邻苯二甲酸二乙酯(DEP)水平的合并效应值分别为1.17(95%CI:0.64~1.69)、0.80(95%CI:0.13~1.48)和0.72(95%CI:-0.19~1.63),尿液中邻苯二甲酸单乙基己基酯(MEHP)和邻苯二甲酸单乙酯(MEP)水平的合并效应值分别为1.75(95%CI:-0.45~3.96)和2.75(95%CI:0.36~5.15),文献无异质性(P>0.05)。结论:DBP代谢产物MBP水平升高与人群肥胖有关联,MBP可能会促进人群肥胖的发生。Objective：To evaluate the relationship between the phthalate ester exposure and the population obesity with Meta-analysis, and to provide a new idea for prevention and control of obesity.Methods：A comprehensive search was performed in English databases（Pubmed,Web of Science,The Cochrane Library,Elsevier Science Direct and OVID）and Chinese databases（Sinomed database,CNKI database,VIP database,Wanfang database）.The studies about the relationship between phthalate ester exposure and the population obesity were retriveded.The Chinese and English studies were selected according to the inclusion criteria and exclusion criteria.Meta-analysis was performed using RevMan 5.3software.Results：Six studies were finally obtained,involving 1259 samples.The Meta-analysis results showed that the monobutyl phthalate（MBP）level in urine of the obesity population was increased 4.1times compared with the normal population（95%CI：1.43-6.76）;while the combined effect values of dibutyl phthalate（DBP）,di-2-ethylhexyl phthalate（DEHP）and diethyl phthalate（DEP）level in serum of the population in two groups were 1.17（95%CI：0.64-1.69）,0.80（95%CI：0.13-1.48）,and 0.72（95% CI：-0.19-1.63）;the combined effect values of monoethylhexyl phthalate（MEHP）and monoethyl phthalate（MEP）levels in urine were 1.75（95%CI：-0.45-3.96）and 2.75（95%CI：0.36-5.15）;there were no significant differences（P〉0.05）.Conclusion：The elevated MBP levels in the urine may be a risk factor for obesity in the population,suggesting that MBP may contribute to obesity.

关 键 词：邻苯二甲酸酯类 肥胖 人群暴露 META分析 

分 类 号：R121[医药卫生—环境卫生学] R589.2[医药卫生—公共卫生与预防医学]