药物涂层球囊在冠状动脉分叉病变边支介入治疗中的临床应用  

Application of drug-coated balloon in treatment of coronary artery bifurcation lesions

作　　者：赵宇[1] 白静[1] 刘庆艳[1] 邓磊[1] 苏绍萍[1] 王禹[1] ZHAO Yu BAI Jing LIU Qing-yan et al(Department of Cardiology, Chinese PLA General Hospital, Beij ing 100853, China)

机构地区：[1]解放军总医院心内科,北京100853

出　　处：《中华老年心脑血管病杂志》2017年第4期388-390,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨药物涂层球囊应用于冠状动脉分叉病变边支血管保护的可行性分析。方法选择2015年3月~2016年3月在解放军总医院经冠状动脉造影证实冠状动脉分叉病变患者20例,Medina分型1,1,1;1,0,1;0,1,1,分别为11、5、4例。行PCI,于主支血管置入药物洗脱支架,边支血管用药物涂层球囊主动保护技术处理,术后即刻冠状动脉造影检查。术后6个月临床随访,统计患者主要心脑血管不良事件。结果20例患者PCI成功率为100%。20例患者主支置入药物洗脱支架,边支血管用药物涂层球囊主动保护技术处理,主支血管最小管腔直径由术前(1.49±0.46)mm增加至术后(3.20±0.53)mm(P=0.001),分支血管由术前(1.36±0.66)mm增加至术后(1.78±0.61)mm(P=0.048)。术后6个月患者无主要心脑血管不良事件发生。结论药物涂层球囊主动保护技术应用于冠状动脉分叉病变边支血管保护安全、有效。Objective To study the application of drug-coated balloon in treatment of coronary ar tery bifurcation lesions. Methods Twenty patients with coronary artery bifurcation lesions admitted to our hospital from March 2015 to March 2016 were included in this study. The patients underwent PCI. Soon after drug-eluting stent was placed into the main branch and the side branch was protected with drug-coated balloon, the patients underwent coronary angiography and were followed up after 6 months of operation. The MACCE were recorded. Results The success rate of PCI was 100%. Drug-eluting stent was placed into the main branch and the side branch was pro tected with drug-coated balloon. The minimal lumen diameters of the main branch and side branch increased from 1.49±0.46 mm and 1.36±0.66 mm respectively before operation to 3.20±0.53 mm and 1.78±0. 61 mm respectively after operation （P=0. 048,P=0. 001）. No MACCE occurred in 6 months after operation. Conclusion Drug-coated balloon is safe and effective in protecting side branch and can thus be used in treatment of coronary artery bifurcation lesions.

关 键 词：药物洗脱支架 冠状血管造影术 冠状动脉再狭窄 药物载体 

分 类 号：R543.3[医药卫生—心血管疾病]