重庆市抗菌药物使用调查及干预前后对比分析研究  

Investigation of antibiotic use and a comparative analysis of therapeutic efficacy before and after intervention

作　　者：周欣[1] 姚高琼[1] 张成志[1] 朱深银[1] 杨佳丹[1] 赵青青[1] 李欣宇[1] Zhou Xin Yao Gaoqiong Zhang Chengzhi Zhu Shenyin Yang J iadan Zhao Qingqing Li Xinyu(Department of Pharmacy ,the First Affiliated Hospital of Chongqing Medical University ,Chongqing 400016 ,China)

机构地区：[1]重庆医科大学附属第一医院药学部,400016

出　　处：《重庆医学》2017年第11期1508-1510,共3页Chongqing medicine

基　　金：重庆市卫计委项目(2013-2-007)

摘　　要：目的探讨干预前后重庆市使用抗菌药物的合理性与干预措施实施的效果。方法采用回顾性调查方法,以参加卫计委抗菌药物监测网重庆分网(重庆分网)的45家单位2011年上报的16 200份病例、54 000张门诊处方及年平均抗菌药物消耗量为干预前组,2012-2014年上报的48 600份病例、162 000张门诊处方及年平均抗菌药物消耗量为干预后组,对门诊抗菌药物使用率、住院患者抗菌药物使用强度、住院患者抗菌药物使用百分率、住院患者抗菌药物平均使用天数、住院患者抗菌药物联合使用率等抗菌药物合理用药指标进行回顾性对照研究,并对数据统计分析。结果各指标较干预前均逐年明显改善:除2012年门诊抗菌药物使用率、住院患者抗菌药物使用强度与2011年比较差异无统计学意义外,其余指标包括住院患者抗菌药物使用百分率、住院患者抗菌药物平均使用天数(d)、住院患者抗菌药物联合使用率与2011年比较差异均有统计学意义。结论临床药师参与临床合理用药,采取多种强有力的干预措施,规范化使用抗菌药物是可行的。Objective To investigate the rationality of antibiotic use in Chongqing before and after intervention and its inter vention effect. Methods 16 200 cases,54 000 outpatient prescriptions and annual average antimicrobial consumption in 2011 from Chongqing sub-network of Health and Family Planning Commission antibacterial drug monitoring network were selected as control group ; 48 600 cases, 162 000 outpatient prescriptions and annual average antimicrobial consumption from 2012 to 2014 were selected as intervention group. The use rate of antimicrobial agents in outpatients, the intensity of antimicrobial use in hospitalized patients, the percentage of antimicrobial use in hospitalized patients, the average number of antimicrobial use in hospitalized patients, the combined use of antibiotics and other antimicrobial agents in hospitalized patients were retrospectively studies. Results Except for the utilization rate of antibiotics in the outpatients and the density of antimicrobial agents in hospitalized patients, the utilization rate of antibiotics in the hospitalized patients, the microbiology inspection rate of application of antibiotics in non surgical treatment （%）, the average use days of antibiotics in the hospitalized patients（days） and the combination rate of antibiotics in the hospitalized patients from 2012 to 2014 （after intervention） had significant impact in comparison with 2011 （before intervention）. Conclusion Through the clinical pharmacistes＇ participating in the intervention in reasonable use of antibiotics and a variety of powerful inter- vention measures, the rationality of antibiotic use is feasible.

关 键 词：抗菌药 干预措施 对比分析 

分 类 号：R95[医药卫生—药学]