中年高血压患者阿司匹林抵抗及其相关危险因素分析  

Risk factors analysis of aspirin resistance in middle-aged hypertensive patients

作　　者：王巍东[1,2] 王晶晶[3] 李闯[2] 贺立山[1] 

机构地区：[1]新乡医学院第一附属医院血液内科,河南卫辉453100 [2]新乡医学院第三附属医院输血科,河南新乡453003 [3]新乡医学院第一附属医院肿瘤科,河南卫辉453100

出　　处：《新乡医学院学报》2017年第3期216-219,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨中年高血压患者发生阿司匹林抵抗的危险因素。方法应用血栓弹力图测定2012年5月至2015年4月在新乡医学院第三附属医院就诊的中年高血压患者177例,根据是否发生阿司匹林抵抗分为阿司匹林抵抗组和阿司匹林敏感组,比较2组患者的一般临床资料。根据患者血压控制水平分为血压达标组(收缩压<140 mm Hg,舒张压<90 mm Hg,1 mm Hg=0.133 k Pa)和血压不达标组(收缩压≥140 mm Hg或舒张压≥90 mm Hg),比较2组患者阿司匹林抵抗发生率情况,并对中年高血压患者发生阿司匹林抵抗的危险因素进行logistic回归分析。结果中年高血压患者177例中阿司匹林抵抗发生率为21.5%(38/177)。血压达标组患者阿司匹林抵抗发生率为11.8%(10/85),血压不达标组患者阿司匹林抵抗发生率为30.4%(28/92),血压不达标组患者阿司匹林抵抗发生率显著高于血压达标组(χ~2=8.978,P<0.05)。阿司匹林抵抗组患者体质量、空腹血糖均显著高于阿司匹林敏感组(P<0.05);阿司匹林抵抗组较阿司匹林敏感组女性比例高(P<0.05);logistic回归分析显示,空腹血糖、女性为阿司匹林抵抗的独立危险因素(P<0.05)。结论中年高血压患者出现阿司匹林抵抗时,有较多的女性患者,阿司匹林抵抗的发生与患者空腹血糖和血压控制相关。Objective To evaluate the risk factors of aspirin resistance in middle-aged hypertensive patients. Methods Thromboela-stogram（ TEG） was used to identify the aspirin resistance in 177 middle-aged hypertensive patients in the Third Affiliated Hospital of Xinxiang Medical University from May 2012 to April 2015. The patients were divided into aspirin resistance group and aspirin sensitivity group according to whether or not the patients with aspirin resistance. All the patients were treated with aspirin for 10 days,then the inhibition ratio of platelet induced by arachidonic acid was determined. The clinical data of patients was compared between the two groups. The patients were divided into normal blood pressure group（ systolic blood pressure 140 mm Hg and diastolic blood pressure 〈90 mm Hg,1 mm Hg = 0. 133 k Pa） and high blood pressure group（ systolic blood pressure≥140 mm Hg or diastolic blood pressure≥90 mm Hg） according to the levels of blood pressure of the patients. The incidence of aspirin resistance was compared between the two groups,logistic regression analysis was used to analyze the risk factors of aspirin resistance in middle-aged hypertensive patients. Results The incidence rate of aspirin resistance in middle-aged hypertensive patients was 21. 5%（ 38 /177）. The incidence rate of aspirin resistance was 11. 8%（ 10 /85）,30. 4%（ 28 /92） in the normal blood pressure group and high blood pressure group respectively; the incidence of aspirin resistance in high blood pressure group was significantly higher than that in the normal blood pressure group（ χ2= 8. 978,P 〈0. 05）. The body weight,fasting blood glucose of patients in aspirin resistance group was significantly higher than that in the aspirin sensitivity group（ P 〈 0. 05）. The number of female in aspirin resistance group was significantly higher than that in the aspirin sensitivity group（ P 〈 0. 05）. Logistic regression analysis showed that fasting blood glucose,women was the independent risk factors fo

关 键 词：中年高血压 血栓弹力图仪 阿司匹林抵抗 阿司匹林敏感 

分 类 号：R544.1[医药卫生—心血管疾病]