慢性心力衰竭患者尿酸水平与其预后的关系研究  

Study on the relationship between uric acid level and prognosis in patients with chronic heart failure

作　　者：赵倡武[1] 张颖[1] 乔雯雯[1] 

机构地区：[1]焦作市第二人民医院河南理工大学第一附属医院心内科二区,454001

出　　处：《国际医药卫生导报》2017年第8期1171-1174,共4页International Medicine and Health Guidance News

摘　　要：目的研究慢性心力衰竭（CHF）患者尿酸（UA）水平与其预后的关系。方法选取本院2014年1月至2015年1月期间收治的78例CHF患者，按CHF严重程度分为A组轻度29例、B组中度26例、C组重度23例，以UA氧化酶法测定并比较三组血尿酸（BUA）浓度，并随访了解和比较三组预后情况。结果三组治疗前、治疗后BUA水平比较差异有统计学意义（P〈0．05），B、C两组治疗前、治疗后BUA水平显著高于A组（P〈0．05）。A、B、C三组再入院率分别为13．79％、42．30％、82．61％，再入率明显逐次增高，差异有统计学意义（P〈0．05），B组再人院率明显高于A组（P〈0．05）；HUA并发率分别为3．49％、23．07％、73．91％，发生率明显逐次增高，差异有统计学意义（P〈0．05），B组HUA并发率明显高于A组（P〈0．05）；A、B、C三组死亡率分别为0．00％、3．85％、13．04％，逐次增高，差异有统计学意义（P〈0．05），A、B组死亡率比较差异无统计学意义（P〉0．05）。结论CHF患者病症严重程度与BUA水平成正比，且BUA水平越高，CHF患者再入院率、HUA并发率及死亡率越高，故临床建议对CHF患者进行BUA水平控制。Objective To study the relationship between uric acid （UA） level and prognosis in patients with chronic heart failure （CHF）. Methods Seventy-eight patients with CHF admitted in our hospital between January 2014 and January 2015 were divided into group A （mild, 29 cases）, group B （moderate, 26 cases）, and group C （severe, 23 cases） according to the severity of CHF. The concentrations of blood uric acid （BUA） were measured and compared among the three groups by UA oxidase method, and the prognosis was also compared. Results There were statistically significant differences in BUA levels before and after treatment among the three groups （P〈0.05）, the BUA levels before and after treatment in group B, C were significantly higher than those in group A （P〈0.05）. The readmission rates in group A, B, and C were 13.79%, 42.30%, and 82.61% respectively （P〈0.05）, and the readmission rate in group B was significantly higher than that in group A （P〈0.05）. The incidences of hyperuricemia （HUA） in group A, B, and C were 3.49%, 23.07%, and 73.91% respectively （P〈0.05）, and the incidence of HUA in group B was significantly higher than that in group A （P〈0.05）. The mortality rates in group A, B, and C were 0.00%, 3.85%, and 13.04% respectively （P〈0.05）, and there was no statistically significant difference in the mortality rate between group A and group B （P〉0.05）. Conclusion The severity of CHF is directly proportional to -UA level, and the higher BUA level is, the higher readmission rate, incidence of HUA, and mortality rate are. It is recommended that BUA level be controlled.

关 键 词：慢性心力衰竭 血尿酸 预后 

分 类 号：R541.6[医药卫生—心血管疾病]