Ultrasonographic evaluation of enthesitis in patients with ankylosing spondylitis  

作　　者：Huayong Zhang Jun Liang Junlan Qiu Fan Wang Lingyun Sun 

机构地区：[1]Department of Rheumatologyand Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210008,China [2]Departments of Rheumatology and Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210008,China [3]Ultrasound Intervention,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210008,China

出　　处：《The Journal of Biomedical Research》2017年第2期162-169,共8页生物医学研究杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81671608,81202350,81571586 and 81302559);Pfizer Competitive Grant(WS1620920);Jiangsu Six Talent Peaks Project(2015-WSN-074);Jiangsu 333 High Level Talents Project;Jiangsu Government Scholarship for Overseas Studies;Jiangsu Health International Exchange Program sponsorship;Nanjing Young Medical Talents Project;Nanjing Health Bureau Key Project(ZKX15018)

摘　　要：The aim of this study was to assess sensitivity and responsiveness of power Doppler ultrasound （PDUS） in detecting enthesitis for ankylosing spondylitis （AS） patients compared to clinical examinations. Twenty AS patients initiating etanerceptunderwent clinical and PDUS examinations of six bilateral entheseal sites at baseline and after 1, 2 and 3 months of treatment. Clinical and PDUS examinations identified at least one entheseal lesion in nine （45%） and 19 （95%） patients, respectively. Furthermore, of 240 entheseal sites examined in these 20 patients, PDUS detected 123 entheseal lesions （51.3% of sites）, compared with only 47 entheseal lesions （19.6%） detected by clinical examination （P〈0.05）. The entheseal lesions found on PDUS were most commonly identified by calcification （33.3%）, tendon edema （29.2%）, abnormal blood flow （25.8%）, a thickened tendon （22.1%）, cortical irregularity （12.9%）, bony erosions （9.6%） and bursitis at the tendon insertion to the bone cortex （7.1%）. Improvements in clinical symptoms and laboratory parameters, and significant decreases in PDUS scores were observed following treatment with etanereept. Improvements in PDUS scores continued during follow-up in patients who entered remission following treatment. In conclusion, PDUS improves detection of structural and inflammatory abnormalities of the enthesis in AS compared to physical examination. In addition, PDUS may be useful inascertaining medications.The aim of this study was to assess sensitivity and responsiveness of power Doppler ultrasound （PDUS） in detecting enthesitis for ankylosing spondylitis （AS） patients compared to clinical examinations. Twenty AS patients initiating etanerceptunderwent clinical and PDUS examinations of six bilateral entheseal sites at baseline and after 1, 2 and 3 months of treatment. Clinical and PDUS examinations identified at least one entheseal lesion in nine （45%） and 19 （95%） patients, respectively. Furthermore, of 240 entheseal sites examined in these 20 patients, PDUS detected 123 entheseal lesions （51.3% of sites）, compared with only 47 entheseal lesions （19.6%） detected by clinical examination （P〈0.05）. The entheseal lesions found on PDUS were most commonly identified by calcification （33.3%）, tendon edema （29.2%）, abnormal blood flow （25.8%）, a thickened tendon （22.1%）, cortical irregularity （12.9%）, bony erosions （9.6%） and bursitis at the tendon insertion to the bone cortex （7.1%）. Improvements in clinical symptoms and laboratory parameters, and significant decreases in PDUS scores were observed following treatment with etanereept. Improvements in PDUS scores continued during follow-up in patients who entered remission following treatment. In conclusion, PDUS improves detection of structural and inflammatory abnormalities of the enthesis in AS compared to physical examination. In addition, PDUS may be useful inascertaining medications.

关 键 词：power Doppler ultrasound ENTHESITIS ankylosing spondylitis 

分 类 号：R593.23[医药卫生—内科学]