JCB:细胞核内钙信号可改变T细胞应答,有助开发免疫抑制疗法  

Nuclear calcium is required for human T cell activation

作　　者：Sara Monaco Beate Jahraus Yvonne Samstag Hilmar Bading 

机构地区：[1]Interdisciplinary Center for Neurosciences, Department of Neurobiology, Heidelberg University, 69120 Heidelberg, Germany [2]Institute of Immunology, Section Molecular Immunology, Heidelberg University, 69120 Heidelberg, Germany [3]Institute of Immunology, Section Molecular Immunology, Heidelberg University, 69120 Heidelberg, Germany [4]Interdisciplinary Center for Neurosciences, Department of Neurobiology, Heidelberg University, 69120 Heidelberg, Germany

出　　处：《现代生物医学进展》2017年第8期I0004-I0004,共1页Progress in Modern Biomedicine

摘　　要：组成免疫系统的免疫细胞可以区分“自己”和“非己”的蛋白分子。比如，如果我们暴露于细菌或病毒等病原体，而这些病原体表面带有外来分子，机体就会做出免疫应答。相比之下，免疫细胞会对机体自身的分子产生耐受。Calcium signals in stimulated T cells are generally considered single entities that merely trigger immune responses, whereas costimulatory events specify the type of reaction. Here we show that the “T cell calcium signal” is a composite signal harboring two distinct components that antagonistically control genomic programs underlying the immune response. Using human T cells from healthy individuals, we establish nuclear calcium as a key signal in human T cell adaptogenomics that drives T cell activation and is required for signaling to cyclic adenosine monophosphate response element-binding protein and the induction of CD25, CD69, interleukin-2, and γ-interferon. In the absence of nuclear calcium signaling, cytosolic calcium activating nuclear factor of activated T cells translocation directed the genomic response toward enhanced expression of genes that negatively modulate T cell activation and are associated with a hyporesponsive state. Thus, nuclear calcium controls the T cell fate decision between a proliferative immune response and tolerance. Modulators of nuclear calcium-driven transcription may be used to develop a new type of pro-tolerance immunosuppressive therapy.

关 键 词：免疫应答 免疫抑制 T细胞 钙信号 细胞核 疗法 开发 蛋白分子 

分 类 号：S852.4[农业科学—基础兽医学]