嗅觉刺激健康成年人诱发的脑功能磁共振成像初步研究  

Brain functional magnetic resonance imaging characteristics induced by olfactory stimulations in healthy adults

作　　者：周小燕[1] 罗程[2] 王晓明[1] 侯昌月 张耀丹[1] 谭娟[1] 杨飞[1] 

机构地区：[1]川北医学院附属医院神经内科、川北医学院神经疾病研究所,四川省南充市637000 [2]电子科技大学生命科学院与技术学院神经信息教育部重点实验室

出　　处：《中华神经科杂志》2017年第4期288-291,共4页Chinese Journal of Neurology

摘　　要：目的观察健康成年人在嗅觉刺激下的脑功能磁共振成像（fMRI）特点，为探索嗅觉障碍脑机制及神经变性疾病的早期诊断提供帮助。方法采用前瞻性研究方法，于2015年3—10月在川北医学院附属医院招募健康成年志愿者21名，并使用视觉模拟量表（VAS）评估嗅觉功能。所有受试者行薰衣草溶液、玫瑰溶液挥发气体刺激嗅觉，同步行fMRI扫描，观察研究对象脑区的激活情况。采用脑功能数据处理软件metlab2008a、SPM8分析图像数据。结果（1）21名健康志愿者的平均VAS评分为（4.86±0.07）分，所有受试者的嗅觉功能均正常；（2）任务态激活脑区包括：双侧顶下小叶、双侧额下叶回-眶额回、左侧岛叶、双侧颞下回、左侧壳核、双侧海马旁回、双侧扣带回、双侧梨状皮质、双侧杏仁核、左侧舌叶、双侧小脑（t＝2.62，P〈0.01）。结论有多个脑区参与了嗅觉处理，联合嗅觉事件相关设计和任务态fMRI扫描可以初步定位嗅觉高级中枢的脑功能活化区，在临床上可将其作为嗅觉功能检测的客观方法之一。ObjectiveTo explore the features of activation mapping induced by olfactory stimulation with functional magnetic imaging （fMRI）, which will help to reveal the neural mechanism of olfactory dysfunction and contribute to the earlier diagnosis and treatment of neural degenerative disorders.MethodsIn this prospective study, 21 healthy volunteers were recruited in the Affiliated Hospital of North Sichuan Medical College from March to October 2015. Olfactory function was evaluated by using Visual Analogue Scale （VAS）. During the fMRI scanning, all subjects received olfactory stimulation of rose and lavender odor. The brain activation was obtained by using softwares matlab2008a and SPM8.ResultsAll subjects had normal olfactory function evaluated by VAS score （4.86±0.07）. The activated brain areas included： bilateral inferior parietal lobule, bilateral inferior frontal gyrus-orbitofrontal gyrus, left insula, bilateral inferior temporal gyrus, left putamen, bilateral hippocampus, bilateral cingulate cortex, bilateral piriform cortex, bilateral amygdale, left lingual gyrus, bilateral cerebellum （t=2.62, P〈0.01）.ConclusionsOlfactory is associated with multiple brain regions. The combination of olfactory event-related design and fMRI, as an objective measurement of olfactory, can be applied to investigate the olfactory cortical brain mapping.

关 键 词：成年人 嗅觉 磁共振成像 脑 

分 类 号：R445.2[医药卫生—影像医学与核医学]