A cryptic mitochondrial DNA link between North European and West African dogs  

作　　者：Adeniyi C.Adeola Sheila C.Ommeh Jiao-Jiao Song S.Charles Olaogun Oscar J.Sanke Ting-Ting Yin Guo-Dong Wang Shi-Fang Wu Zhong-Yin Zhou Jacqueline K.Lichoti Bernard R.Agwanda Philip M.Dawuda Robert W.Murphy Min-Sheng Peng Ya-Ping Zhang Adeniyi C. Adeola Sheila C. Ommeh Jiao-Jiao Song S. Charles Olaogun Oscar J. Sanke Ting-Ting Yin Guo-Dong Wang Shi-Fang Wu Zhong-Yin Zhou Jacqueline K. Lichoti Bernard R. Agwanda Philip M.＇Dawuda Robert W. Murphy Min-Sheng Peng Ya-Ping Zhang(State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Germplasm Bank of Wild Species, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming 650223,China;Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China;Animal Biotechnology Group, Institute of Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology, Nairobi 00200, Kenya;Institute of Health Sciences, Anhui University, Hefei 230601, China;Department of Veterinary Medicine, University of Ibadan, lbadan 200284, Nigeria;Taraba State Ministry of Agriculture and Natural Resources, Jalingo 660221, Nigeria;Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technoloooy of China, Hefei 230026, China;State Department of Livestock, Ministry o.f Agriculture Livestock and Fisheries, Nairobi 00100, Kenya;Department of Zoology, National Museums of Kenya, Nairobi 00100, Kenya;Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Makurdi 972261, Nigeria;Centre for Biodiversity and Conservation Biolo-gy, Royal Ontario Museurn, Toronto MSS 2C6, Canada;State Key Laboratory for Conservation and Utiiizati＇on of Bio-Resources, Yunnan University, Kunming 650091, China)

机构地区：[1]State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Germplasm Bank of Wild Species, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China [2]Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming 650223, China [3]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China [4]Animal Biotechnology Group, Institute of Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology, Nairobi 00200, Kenya [5]Institute of Health Sciences, Anhui University, Hefei 230601, China [6]Department of Veterinary Medicine, University of Ibadan, lhadan 200284, Nigeria [7]Taraba State Ministry of Agriculture and Natural Resources, Jalingo 660221, Nigeria [8]Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China [9]State Department of Livestock, Ministry of Agriculture Livestock and Fisheries, Nairobi 00100, Kenya [10]Department of Zoology, National Museums of Kenya, Nairobi 00100, Kenya [11]Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Makurdi 972261, Nigeria [12]Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto M5S 2C6, Canada [13]State Key Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, China

出　　处：《Journal of Genetics and Genomics》2017年第3期163-170,共8页遗传学报（英文版）

基　　金：supported by Sino-Africa Joint Research Center, Chinese Academy of Sciences (Nos. SAJC201611 and SAJC201306);the National Basic Research program (Nos. 2013CB835200 and 2013CB835202);The Youth Innovation Promotion Association, Chinese Academy of Sciences, provided support to M.S.P. and G.D.W.;supported by the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences (the Large Research Infrastructure Funding);supported, in part, by a Visiting Professorship for Senior International Scientists from the Chinese Academy of Sciences;manuscript preparation by a Natural Sciences and Engineering Research Council of Canada Discovery Grant A3148 to R.W.M

摘　　要：Domestic dogs have an ancient origin and a long history in Africa. Nevertheless, the timing and sources of their introduction into Africa remain enigmatic. Herein, we analyse variation in mitochondrial DNA（mt DNA） D-loop sequences from 345 Nigerian and 37 Kenyan village dogs plus 1530 published sequences of dogs from other parts of Africa, Europe and West Asia. All Kenyan dogs can be assigned to one of three haplogroups（matrilines; clades）： A, B, and C, while Nigerian dogs can be assigned to one of four haplogroups A, B, C, and D. None of the African dogs exhibits a matrilineal contribution from the African wolf（Canis lupus lupaster）. The genetic signal of a recent demographic expansion is detected in Nigerian dogs from West Africa. The analyses of mitochondrial genomes reveal a maternal genetic link between modern West African and North European dogs indicated by sub-haplogroup D1（but not the entire haplogroup D） coalescing around 12,000 years ago. Incorporating molecular anthropological evidence,we propose that sub-haplogroup D1 in West African dogs could be traced back to the late-glacial dispersals, potentially associated with human hunter-gatherer migration from southwestern Europe.Domestic dogs have an ancient origin and a long history in Africa. Nevertheless, the timing and sources of their introduction into Africa remain enigmatic. Herein, we analyse variation in mitochondrial DNA（mt DNA） D-loop sequences from 345 Nigerian and 37 Kenyan village dogs plus 1530 published sequences of dogs from other parts of Africa, Europe and West Asia. All Kenyan dogs can be assigned to one of three haplogroups（matrilines; clades）： A, B, and C, while Nigerian dogs can be assigned to one of four haplogroups A, B, C, and D. None of the African dogs exhibits a matrilineal contribution from the African wolf（Canis lupus lupaster）. The genetic signal of a recent demographic expansion is detected in Nigerian dogs from West Africa. The analyses of mitochondrial genomes reveal a maternal genetic link between modern West African and North European dogs indicated by sub-haplogroup D1（but not the entire haplogroup D） coalescing around 12,000 years ago. Incorporating molecular anthropological evidence,we propose that sub-haplogroup D1 in West African dogs could be traced back to the late-glacial dispersals, potentially associated with human hunter-gatherer migration from southwestern Europe.

关 键 词：Dog Mitochondrial DNA Africa Haplogroup D Late-glacial dispersal HYBRIDIZATION 

分 类 号：S829.2[农业科学—畜牧学]