Identification and analysis of intermediate-size noncoding RNAs in the rhesus macaque fetal brain  

作　　者：Liyuan Zhu Xiaochao Tan Wei Liu Fengbiao Mao Chao Wu Junjie Zhou Xiao Liu Shuaiyao Lu Kaili Ma Bin Yin Jianjun Luo Jiangang Yuan Boqin Qiang Runsheng Chen Liyuan Zhu;Xiaochao Tan;Wei Liu;Fengbiao Mao;Chao Wu;Junjie Zhou;Xiao Liu;Shuaiyao Lu;Kaili Ma;Bin Yin;Jianjun Luo;Jiangang Yuan;Boqin Qiang;Runsheng Chen;Xiaozhong Peng(State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China;Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China;Institute of Medical Biology, Chinese Academy of Medical Sciences, CAMS ＆ PUMC, Kunming 650118, China;Medical Primate Research Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China;Bioinformatics Laboratory and CAS Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China)

机构地区：[1]State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China [2]Beijing Institutes of Life Science, Chinese Academy of Sciences, Belting 100101, China [3]Institute of Medical Biology, Chinese Academy of Medical Sciences, CAMS ＆ PUMC Kunming 650118, China [4]Medical Primate Research Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China [5]Bioinformatics Laboratory and CAS Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

出　　处：《Journal of Genetics and Genomics》2017年第3期171-174,共4页遗传学报（英文版）

基　　金：supported by the grants from the National Key Research and Development Plan (2016YFA0100702,2016YFC0902502);the National Key Basic Research Program (973 Program) (Nos.2013CB531304 and 2011CBA01104);the National Sciences Foundation of China (Nos. 31301152,31670789,31671316,31370789 and 30825023);CAMS Innovation Fund for Medical Sciences (CIFMS,2016-I2M-2-001,2016-I2M-1-001,2016-I2M-1-004)

摘　　要：Although only about 2%of the human genome has proved to be protein-coding genes,recent advances in genome wide analysis have revealed that the majority of the genome is transcribed,mainly from noncoding segments that were once considered＂junk sequences＂or＂dark matters＂（Liu et al.,2011a;Zhang et al.,2014b）. In addition to the well-characterized housekeeping non- coding RNAs （ncRNAs） （tRNA, rRNA, small nuclear RNA and small nucleolar RNAs） and some small regulatory ncRNAs （microRNAs and small interfering RNAs）, the transcriptome of mammals could also pervasively have been transcribed long noncoding RNAs （lncRNAs, at least 200 nt） （Rinn and Chang, 2012; Xie et al., 2012）.Although only about 2%of the human genome has proved to be protein-coding genes,recent advances in genome wide analysis have revealed that the majority of the genome is transcribed,mainly from noncoding segments that were once considered＂junk sequences＂or＂dark matters＂（Liu et al.,2011a;Zhang et al.,2014b）. In addition to the well-characterized housekeeping non- coding RNAs （ncRNAs） （tRNA, rRNA, small nuclear RNA and small nucleolar RNAs） and some small regulatory ncRNAs （microRNAs and small interfering RNAs）, the transcriptome of mammals could also pervasively have been transcribed long noncoding RNAs （lncRNAs, at least 200 nt） （Rinn and Chang, 2012; Xie et al., 2012）.

关 键 词：RNA Identification and analysis of intermediate-size noncoding RNAs in the rhesus macaque fetal brain 

分 类 号：R346[医药卫生—基础医学]