Regucalcin plays a role in the cytoskeleton regulation of HepG2 cells  

作　　者：Jia Chen Beihui Xu Jiemin Wu Xiangfan Liu Hong Xu Peihua Ni 

机构地区：[1]Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China [2]Department of Clinical Laboratory, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200023, China [3]Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China

出　　处：《Acta Biochimica et Biophysica Sinica》2017年第2期193-195,共3页生物化学与生物物理学报（英文版）

摘　　要：Regucalcin （RGN）, also known as senescence maker protein-30, is a unique calcium-binding protein which lacks of classic EF-hand motif [1]. It is mainly expressed in the liver and kidney and highly conserved in the coding region among eukaryotes [2]. RGN is involved in regulating a series of cellular processes, such as intracel- lular calcium homeostasis, calcium signal transduction, cell metab- olism, function of the nuclei, and gene expression [3-5]. Given that calcium exerts a profound effect on cytoskeleton, and cytoskeleton alteration is closely related to tumor formation, invasion, and metastasis [6], we speculated that RGN might play a role in cyto- skeleton rearrangement and further affect cytoskeleton associated signaling pathways.Regucalcin （RGN）, also known as senescence maker protein-30, is a unique calcium-binding protein which lacks of classic EF-hand motif [1]. It is mainly expressed in the liver and kidney and highly conserved in the coding region among eukaryotes [2]. RGN is involved in regulating a series of cellular processes, such as intracel- lular calcium homeostasis, calcium signal transduction, cell metab- olism, function of the nuclei, and gene expression [3-5]. Given that calcium exerts a profound effect on cytoskeleton, and cytoskeleton alteration is closely related to tumor formation, invasion, and metastasis [6], we speculated that RGN might play a role in cyto- skeleton rearrangement and further affect cytoskeleton associated signaling pathways.

分 类 号：Q245[生物学—细胞生物学] Q513