甲状腺过氧化物酶抗体与孕期甲状腺功能变化及早产的关系  

Relationship between thyroid peroxidase antibody and the changes of thyroid function during pregnancy and preterm birth

作　　者：吴书仪[1] 吴明秀[1] 陈艳雅[1] 罗沛芬[1] 钟树林[1] 禤文婷[1] 

机构地区：[1]广东省东莞市人民医院妇产科,广东东莞523000

出　　处：《广东医学院学报》2016年第5期520-522,共3页Journal of Guangdong Medical College

摘　　要：目的探讨单纯甲状腺过氧化物酶抗体阳性与孕期甲状腺功能变化及早产的关系。方法观察242例单纯甲状腺过氧化物酶抗体阳性孕妇(研究组)与1 958例抗体阴性孕妇(对照组)的自发早产发生率,对比两组孕妇孕期甲状腺功能的变化。结果研究组孕妇早产发生率高于对照组孕妇(17.76%vs 5.01%,P<0.01)。两组孕妇孕期血清血清促甲状腺素(TSH)、游离甲状腺素(FT4)值变化趋势差异无统计学意义(P>0.05)。结论甲状腺过氧化物酶抗体阳性是自发早产的危险因素之一。Objective To investigate the relationship between positive thyroid peroxidase antibody and the changes of thyroid function during pregnancy and preterm birth. Methods In a predictive study, 242 cases of pregnant women with positive thyroid peroxidase antibody（Study Group） and 1 958 cases with negative thyroid peroxidase antibody（Control Group） were observed in terms of the ratio of spontaneous preterm birth, and the changes thyroid function in the two groups were compared. Results Study Group had a higher incidence of preterm birth than Control Group（17.76% vs 5.01%, P〈 0.01）. But there was no statistical difference in the changes of serum FT4 and TSH between the two groups. ConclusionPositive thyroid peroxidase antibody is one of high risk factors causing spontaneous preterm birth.

关 键 词：甲状腺过氧化物酶抗体 自发早产 甲状腺功能 

分 类 号：R714.21[医药卫生—妇产科学]