按体表面积给药测定结核病患者罗库溴铵的药效学参数  

Determination of pharmacodynamic parameters of rocuronium administered based on body surface area in the patients with tuberculosis

作　　者：洪木周 黄小兰[1] 车邦民[1] 刘民强[2] 

机构地区：[1]广东省深圳市宝安区人民医院麻醉科,广东深圳518101 [2]广东省深圳市第三人民医院麻醉科,广东深圳518112

出　　处：《广东医学院学报》2016年第6期609-612,共4页Journal of Guangdong Medical College

基　　金：深圳市宝安区科技计划立项项目(No.2015248)

摘　　要：目的测定按体表面积给药法对结核病患者罗库溴铵(ROC)药效学参数。方法择期行全身麻醉头颈部手术40例,结核病组(TB组)与非结核病组(N组)各20例。各组患者麻醉诱导时按体表面积计算给予2倍ED95 ROC,待拇内收肌四个成串刺激(TOF)第一个肌颤搐反应(T_1)下降至最低值时行气管插管。记录各组起效时间、最大抑制程度、临床作用时间、恢复指数、药理作用时间、气管插管条件,以及麻醉诱导前(t_0)、给予肌松药后5(t_1)、15(t_2)、30(t_3)、45(t_4)、60(t_5)min时的平均动脉压(MAP)和心率(HR)。结果与N组比较,TB组男女比例、体质量指数(BMI)、白蛋白差异无统计学意义(P>0.05);TB组临床作用时间较短(P<0.05);两组T_1最大抑制、起效时间、恢复指数、药理作用时间及血流动力学比较差异无统计学意义(P>0.05)。结论 ROC按体表面积给药测得结核病患者的临床作用时间较一般患者短,但其它药效学参数无显著改变。Objective To determine the pharmacodynamic parameters of rocuronium （ROC） administered based on body surface area in patients with tuberculosis. Methods Forty patients scheduled for head and neck surgery under general anesthesia were randomly divided into tuberculosis group （TB Group） and non-tuberculosis group（Non-TB Group）, 20 cases in each group. Each group was administered with ROC at a dose calculated based on body surface area for anesthesia induction. Endotracheal intubation was conducted when the T1 of train-of-four stimulation （TOF） of the adductor pollicis muscle fell to the lowest. The onset time, the maximum inhibition of T1, the clinical action time, the recovery index, the pharmacological action time and the endotracheal intubation conditions of each group, as well as the HR and MAP before anesthesia induction （to） and at 5 （t0, 15（t2）, 30（t3）, 45（t4）, 60 min（t5） after muscle relaxant was administered were recorded. Results Compared with Non-TB Group, the clinical action time of ROC in TB Group was significantly shorter （P〈0.05）; but there was no statistical difference in terms of the maximum inhibition ofT1, the clinical action time, the recovery index, the pharmacological action time as well as haemodynamics between the two groups （P〉0.05）. Conclusion The clinical action time of ROC administered based on body surface area in the patients with tuberculosis is shorter than that in general patients, but other pharmacodynamic parameters show no significant changes.

关 键 词：结核 罗库溴铵 药效学 

分 类 号：R614[医药卫生—麻醉学]