藏药渣驯及其不同萃取部位抗胃溃疡抗肝损伤作用的比较研究  

Comparative Study ofA ntiulcerogenic and Anti-liver Injury Effects of Different Fraction from Tibetan Medicine Brag-zhun

作　　者：叶翠萍[1] 王文倩[1] 赵明明[1] 曾勇[1] 古锐[1] 

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《中国民族民间医药》2017年第7期39-41,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：江西民族传统药现代科技与产业发展协同创新中心开放基金项目(JXXT201402008-1);国家自然科学基金面上项目(313911)

摘　　要：目的:研究藏药渣驯及其不同萃取部位的抗胃溃疡、抗肝损伤作用,初步探讨其药效物质基础。方法:采用消炎痛致小鼠胃溃疡模型考察渣驯及其不同萃取部位的抗胃溃疡作用;采用刀豆蛋白A(ConA)致小鼠肝损伤模型考察渣驯及其不同萃取部位抗肝损伤作用。结果:渣驯及其水萃取部位、正丁醇部位能明显降低消炎痛所致胃溃疡小鼠的溃疡指数(P<0.05),能够明显降低ConA所致的肝损伤小鼠的肝脏指数(P<0.05),显著降低血清中ALT、AST含量(P<0.01)。结论:藏药渣驯及其水萃取部位、正丁醇部位可能为渣驯治疗胃溃疡和肝损伤的有效物质基础,其作用机制有待进一步研究。Objective To investigate the protective effectof different fraction from Tibetan medicine Brag-zhun on ulcerogenic andliver injury,primary discussion for the efficacy material base.Methods The gastric ulcer model induced by indomethacin was adopted in the research of antiulcerogenic effect,and the liver injury modelinduced by Concanavalin A was observed in the study of anti-liver injuryeffect.Results Brag-zhun and its water extraction parts, n-butyl alcohol parts can obviously reduce the ulcer index of indomethacin-induced gastric ulcer in mice （P〈0.05）, can significantly reduce liver index of Con A-induced liver injury in mice（P〈0.05）, significantly lower serum ALT, AST levels （P〈0.01）.Conclusion Tibetan brag-zhunand its water extraction parts, n-butyl alcohol parts maybe the efficacy material base for the treatment of the gastric ulcer and the liver injury , its mechanism needs further research.

关 键 词：渣驯 萃取部位 消炎痛 胃溃疡 肝损伤 

分 类 号：R285.5[医药卫生—中药学]