新型5-氟尿嘧啶-吲哚菁染料偶合物的合成  

Synthesis of Novel 5-Fluorouracil-coupled Indocyanine Dye Compounds

作　　者：王时雨[1] 张俊娜[1] 冀楠[1] 张婧芳[1] 何炜[1] 

机构地区：[1]第四军医大学药学院化学教研室,陕西西安710032

出　　处：《合成化学》2017年第4期308-312,共5页Chinese Journal of Synthetic Chemistry

基　　金：陕西省科技统筹计划重点项目(2012KTCQ03-02)

摘　　要：以抗癌药5-氟尿嘧啶和近红外荧光探针IR780和IR783为原料,经取代、乙酸化和酰胺化反应合成了两种新型的双效抗肿瘤药物5-FU-780和5-FU-783,其结构经~1H NMR,^(13)C NMR,IR和HR-MS表征。Two new 5-fluorouracil-coupled indocyanine dye compounds （5-FU-780 and 5-FU-783 ） were synthesized via substitution, acetoxylation and amidation reaction, using antitumor drug 5-fluorou- racil and near-infrared fluorescent dyes IR780 and IR783 as the starting materials. The structures were characterized by 1H NMR, 13C NMR, IR and HR-MS.

关 键 词：5-氟尿嘧啶 近红外荧光探针 IR780 IR783 5-氟尿嘧啶-吲哚菁染料偶合物 合成 抗肿瘤药物 

分 类 号：R979.1[医药卫生—药品] O621.3[医药卫生—药学]