复发性自然流产患者自身抗体和甲状腺功能的检测及临床意义  

Clinical Significance of Autoantibodies and Thyroid Function in Patients with Recurrent Spontaneous Abortion

作　　者：杜静[1] 郑宝珠[1] 夏勇[1] 晏耀明[1] 唐晖[1] 周薇[1] 陆红[1] 杨超 

机构地区：[1]北京大学深圳医院检验科,广东深圳518036 [2]深圳市人民医院外科,广东深圳518020

出　　处：《现代检验医学杂志》2017年第2期98-101,105,共5页Journal of Modern Laboratory Medicine

摘　　要：目的分析复发性自然流产(RSA)患者血清抗核抗体(ANA)、抗甲状腺过氧化物酶抗体(TPO-Ab)、抗甲状腺球蛋白抗体(Tg-Ab)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)的检测结果及临床意义。方法选取2015年3~12月北京大学深圳医院妇产科门诊确诊为RSA的患者46例为疾病组,健康对照(health control,HC)组选择同期无任何不良孕产史的20例女性,采用间接免疫荧光法(IIF)和ELISA方法检测46例RSA患者和50例正常对照血清ANA,采用化学发光法检测TPO-Ab,Tg-Ab,TSH,FT3,FT4。结果 RSA组和对照组血清ANA(IIF),TPO-Ab,Tg-Ab阳性率分别是24%,24%,15%和15%,5%,5%,二者差异有统计学意义(P<0.05)。RSA组和对照组血清TSH,TPO-Ab,Tg-Ab水平分别是2.70±1.38 mIU/L,38.99±10.18 IU/ml,3.07±1.69 IU/ml和2.14±1.32 mIU/L,4.04±1.32 IU/ml,0.64±0.53 IU/ml,二者差异有统计学意义(P<0.05)。结论 ANA和甲状腺抗体阳性可能和RSA发生相关,检测两者水平对于寻找不孕原因及采取适宜干预措施具有重要意义。Objective To study the clinical significance of antinuclear antibody （ANA）, anti-thyroid peroxidase antibody （TPO-Ab） and antithyroglobulin antibody （Tg Ab）, thyroid stimulating hormone （TSH）, free triiodothyronine （FT3）, free thyroxine （FT4） in patients with recurrent spontaneous abortion （RSA）. Methods 46 women with RSA diagnosis in out- patient department in Peking University Shenzhen Hospital from March 2015 to December 2016 were recruited as the study group,20 women with normal childbirth history were enrolled as the control group,ANA was detected by indirect immuno- fluorescence （IIF） assay and ELISA, TSH,FT3 and FT4 were detected by chemiluminescence immunoassay technology. Re- sults The positive rates of ANA（IIF）,TPO-Ab and Tg-Ab in patients with RSA were 24%, 24% and 15% respectively which were significantly higher than those in healthy control （P〈0.05）. Serum levels of TSH ,TPO-Ab and Tg Ab in pa- tients with RSA were 2.70± 1.38 mIU/L, 38.99 ± 10.18 IU/ml and 3.07 ± 1.69 IU/ml respectively, which were signifi- candy higher than those in healthy cases （P〈0.05）. Conclusion ANA and antithyroid antibodies were closely related with RSA. It is very important to screen ANA and antithyroid antibodies for etiological diagnosis and appropriate intervention in patients with RSA to reduce the incidence of abortion.

关 键 词：复发性自然流产 抗核抗体 抗甲状腺抗体 甲状腺功能 

分 类 号：R714.21[医药卫生—妇产科学] R446.62[医药卫生—临床医学]