联合检测血尿酸、血钙、血浆白蛋白预测子痫前期的价值  

Predictive value of joint detection of blood uric acid,blood calcium,and plasma albumin for preeclampsia

作　　者：杨林[1,2] 应小燕[3] 韩雪梅[2] 马致南[2] 

机构地区：[1]南京医科大学,江苏南京211166 [2]扬州市妇幼保健院产科,江苏扬州225001 [3]南京医科大学第二附属医院,江苏南京211166

出　　处：《中国妇幼保健》2017年第7期1372-1374,共3页Maternal and Child Health Care of China

基　　金：扬州市社会发展前瞻性研究项目(YZ2014223)

摘　　要：目的探讨一种易于临床推广的联合预测子痫前期的方法。方法选取2014年1月-2016年6月在扬州市妇幼保健院产科门诊正规产前检查至住院分娩的单胎妊娠孕妇,诊断为子痫前期的患者82例为子痫前期组,其中重度子痫前期患者58例,轻度子痫前期患者24例;随机选取正常妊娠孕妇68例为对照组。两组孕妇均无糖尿病、心脏病、慢性肾炎、免疫系统疾病等妊娠并发症及合并症,比较两组孕妇各项指标的差异。结果子痫前期组孕妇血钙、血浆白蛋白浓度均低于对照组孕妇,血尿酸浓度明显高于对照组孕妇,差异有统计学意义(P<0.05)。58例重度子痫前期孕妇中同时出现两项指标异常的22例,占37.93%;三项异常的29例,占50.00%。24例轻度子痫前期孕妇中同时出现两项指标异常的10例,占41.67%;三项异常的5例,占20.83%。68例对照组孕妇中同时出现两项指标异常的19例,占27.94%;三项异常的3例,占4.41%。对照组与轻、重度子痫前期组比较差异有统计学意义(P<0.05)。单项指标血钙、血尿酸、血浆白蛋白预测子痫前期的灵敏度分别为42.7%、60.7%、65.4%,特异度分别为61.4%、64.7%、32.4%。三项联合预测时灵敏度为93.1%,特异度为86.7%,比单一预测的阳性预测值高。结论血钙、血浆白蛋白、血尿酸可作为子痫前期的有效预测指标,但联合检测可明显提高子痫前期的预测率。Objective To explore a method easy to be popularized in clinic to predict preeclampsia. Methods Eighty-two single pregnant women diagnosed as preeclampsia were selected from Yangzhou Municipal Maternal and Child Health Care Hospital from January 2014 to June 2016 as preeclampsia group,including 58 pregnant women with severe preeclampsia and 24 pregnant women with mild preeclampsia; 68 normal pregnant women were randomly selected as control group. The pregnant women in the two groups had no pregnancy complications,such as diabetes,heart disease,chronic nephritis,and immune system diseases. The differences of various indexes in the two groups were compared. Results The levels of blood calcium and plasma albumin in preeclampsia group were lower than those in control group,while the level of blood uric acid in preeclampsia group was higher than that in control group,there were statistically significant differences（ P〈0. 05）. Among 58 pregnant women with severe preeclampsia,22 pregnant women were found with two abnormal indexes,accounting for 37. 93%; 29 pregnant women were found with three abnormal indexes,accounting for 50. 00%. Among 24 pregnant women with mild preeclampsia,10 pregnant women were found with two abnormal indexes,accounting for 41. 67%; 5 pregnant women were found with three abnormal indexes,accounting for 20. 83%. In control group,19 pregnant women were found with two abnormal indexes,accounting for 27. 94%; 3 pregnant women were found with three abnormal indexes,accounting for 4. 41%. There were statistically significant differences between preeclampsia group and control group（ P〈0. 05）. The sensitivities and specificities of blood calcium,blood uric acid,and plasma albumin in prediction of preeclampsia were 42. 7%,60. 7%,65. 4% and 61. 4%,64. 7%,32. 4%,respectively. The sensitivity and specificity of joint detection of the three indexes were 93. 1% and 86. 7%,respectively,which were higher than those of single application. Conclusion Blood calcium,blood uric acid,and plasma albumin can

关 键 词：联合预测 子痫前期 血钙 血浆白蛋白 血尿酸 

分 类 号：R714.245[医药卫生—妇产科学]