CYP27A1在肿瘤进程中的作用研究进展  

Research progress on the role of CYP27A1 in tumor progression

作　　者：包雪阳[1] 王多伟[1] 杨洪宝[1] 杨勇[1] 

机构地区：[1]中国药科大学药物科学研究院,江苏南京211198

出　　处：《药学研究》2017年第3期170-173,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金青年基金项目(No.81502407);国家自然科学基金(No.81403020);江苏省自然科学基金青年基金项目(No.BK20140666)

摘　　要：CYP27A1是细胞色素P450 27亚族的成员之一,存在于多种组织的线粒体内,其主要功能是通过经典通路和酸性通路催化胆汁酸合成过程中的羟化、维持体内胆汁酸的平衡,催化维生素D_3的生物活化。CYP27A1与多种肿瘤的形成密切相关,如乳腺癌、前列腺癌、结肠直肠癌以及肝癌等,本文总结了CYP27A1在3种常见肿瘤中的作用,以期为肿瘤发生机制研究奠定基础。CYP27A1 is a member of the cytochrome P450,and is commonly known as sterol 27-hydroxylase.This enzyme is located in many different tissues where it is found within the mitochondria.It is most prominently involved in the biosynthesis of bile acidsin both the classic and acidic pathways,thus maintaining the balance of bile acids.The other well-known function is activating vitamin D3 catalytically.CYP27A1 is closely related to the formation of a variety of tumors,suchas breast cancer,prostate cancer,colorectal cancer and liver cancer,etc.This article summarized the main role of CYP27A1in the first three tumors so as to lay the foundation for the research of mechanism of tumorigenesis.

关 键 词：CYP27A1 维生素D3 乳腺癌 前列腺癌 结肠直肠癌 

分 类 号：Q552[生物学—生物化学]