肝纤维化动物模型研究进展与中药药效评价应用概况  

Reach Progress on Animal Models with Hepatic Fibrosis and Its Application in Efficacy Evaluation of Traditional Chinese Medicine

作　　者：窦立雯 孙蓉[2] 

机构地区：[1]山东中医药大学,山东济南250355 [2]山东省中医药研究院,山东济南250014

出　　处：《中国药物警戒》2017年第3期179-182,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金面上项目(81374059);山东省自主创新和成果转化项目(2014ZZCX02104);泰山学者工程专项经费资助(ts201511107)

摘　　要：目的以肝纤维化病因和病机为基础,紧密联系中医临床实际,确定并提出适宜于中医病证研究和中药药效评价的肝纤维化动物模型。方法对近十几年来国内外相关文献对肝纤维化模型的报道进行整理、分析与归纳。结果目前肝纤维化常见的模型多为西医病理模型,其造模方法、机制、特点各不相同,在中药药效评价研究中尚存在模型灵敏性、可靠性、稳定性方面的问题。结论应在中医理论指导下,以临床上肝纤维化的表现为依据,结合中医对肝纤维化的认知和现代医学的融合,研制更符合临床实际和中医理论的肝纤维化病证结合动物模型,为构建中医病因病机及病症演变规律下的、中药药效评价的、稳定可靠的肝纤维化模型奠定基础。Objective To establish the animal model of hepatic fibrosis with the basis of etiology and pathogenesis of hepatic fibrosis and the clinical practice of traditional Chinese medicine （TCM）, which is stable and reliable and is suitable for the activity and efficacy of TCM. Methods References in the last decades at home and abroad about the animal model of hepatic fibrosis were collated, summarized and analyzed. Results There are many medical pathologicals of hepatic fibrosis at present, though the mechanisms and applications of models are different. There are also many problems in the study of the efficacy evaluation and pathological mechanism of TCM, such as sensitivity, reliability and stability of the model. Conclusion We should research hepatic fibrosis animal model which is more in line with actual clinical syndromes and TCM theory on the basis of guidance of Chinese medicine theory, TCM clinical manifestations of hepatic fibrosis, combining modem etiology and pathogenesis study, in order to study the nature of hepatic fibrosis and liver medicine to provide better tools for evaluation,.

关 键 词：肝纤维化 动物模型 中药药效评价 

分 类 号：R965[医药卫生—药理学]