Square wave voltammetric quantification of folic acid,uric acid and ascorbic acid in biological matrix  

作　　者：Majid Arvand Akram Pourhabib Masoud Giahi 

机构地区：[1]Electroanalytical Chemistry Laboratory,Faculty of Science,University of Guilan,NamjooStreet,P.O.Box:1914,Rasht,Iran [2]Education Organization of Guilan Province,Farhang Square,P.O.Box:41849-83111,Rasht,Iran [3]Department of Chemistry,Faculty of Science,Lahijan Branch,Islamic Azad University,P.O.Box:1616,Lahijan,Iran

出　　处：《Journal of Pharmaceutical Analysis》2017年第2期110-117,共8页药物分析学报（英文版）

基　　金：the Post-graduate Office of Guilan University(A-384579)for supporting

摘　　要：Nowadays, modified electrodes with metal nanoparticles have appeared as an alternative for the electroanalysis of various compounds. In this study, gold nanoparticles（GNPs） were chosen as interesting metal nanoparticles for modifying carbon paste electrode（CPE）. GNPs and the gold nanoparticles-modified carbon paste electrode（GNPs/CPE） were characterized by UV–Vis spectroscopy, transmission electron microscopy（TEM） and scanning electron microscopy（SEM）. GNPs/CPE as a simple and sensitive electrode was used to study three important biological molecules： folic acid（FA）, uric acid（UA） and ascorbic acid（AA）. Square wave voltammetry（SWV） was used as an accurate technique for quantitative measurements. A good linear relation was observed between anodic peak current（ipa） and FA（5.2 × 10（-6）– 2.5 × 10（-5）M）, UA（1.2 × 10（-6）– 2.1 × 10（-5）M） and AA（1.2 × 10（-6）– 2.5 × 10（-5）M） concentrations in simultaneous determination of these molecules.Nowadays, modified electrodes with metal nanoparticles have appeared as an alternative for the electroanalysis of various compounds. In this study, gold nanoparticles（GNPs） were chosen as interesting metal nanoparticles for modifying carbon paste electrode（CPE）. GNPs and the gold nanoparticles-modified carbon paste electrode（GNPs/CPE） were characterized by UV–Vis spectroscopy, transmission electron microscopy（TEM） and scanning electron microscopy（SEM）. GNPs/CPE as a simple and sensitive electrode was used to study three important biological molecules： folic acid（FA）, uric acid（UA） and ascorbic acid（AA）. Square wave voltammetry（SWV） was used as an accurate technique for quantitative measurements. A good linear relation was observed between anodic peak current（ipa） and FA（5.2 × 10（-6）– 2.5 × 10（-5）M）, UA（1.2 × 10（-6）– 2.1 × 10（-5）M） and AA（1.2 × 10（-6）– 2.5 × 10（-5）M） concentrations in simultaneous determination of these molecules.

关 键 词：Ascorbic acid Folic acid gold nanoparticles-modified carbon paste electrode Simultaneous determination Uric acid 

分 类 号：O657.1[理学—分析化学]