试验序贯分析检验Cochrane泌尿外科学小组Meta分析假阳性结果的研究  

Examining the false-positive results of meta-analysis of Cochrane urology group using trial sequential analysis

作　　者：翁鸿 王朝阳[2,3] 贺大林[4] 李胜 彭双鹤 曾宪涛[1,6] 

机构地区：[1]武汉大学中南医院循证与转化医学中心武汉大学循证与转化医学中心武汉大学第二临床学院循证医学与临床流行病学教研室,武汉430071 [2]河南大学淮河医院循证医学中心,河南开封475000 [3]河南大学淮河医院普外科,河南开封475000 [4]西安交通大学第一附属医院泌尿外科,西安710061 [5]北京大学第一医院泌尿外科,北京100034 [6]武汉大学中南医院泌尿外科,武汉430071

出　　处：《中国循证医学杂志》2017年第4期458-462,共5页Chinese Journal of Evidence-based Medicine

基　　金：国家重点研发计划专项基金(编号:2016YFC0106300)

摘　　要：目的采用试验序贯分析(TSA)检验Cochrane泌尿外科学小组累积Meta分析假阳性结果。方法计算机检索The Cochrane Library(2016年第6期)"Urology Group"的系统评价,查找具有阳性结果的Meta分析。由2位研究者独立进行文献筛选和资料提取,然后采用TSA 0.9β软件进行TSA。结果共纳入11个Meta分析。TSA结果显示,11个Meta分析中,有8个(72.7%)Meta分析的结论既未穿过TSA界值,也未达到期望信息量,为潜在的假阳性结果。结论 TSA可以辅助判断Meta分析的结果是否为假阳性结果。Objective To detect the false-positive results of cumulative meta-analyses of Cochrane Urology Group with the trial sequential analysis （TSA）. Methods The systematic reviews of Urology Group of The Cochrane Library were searched to collect meta-analyses with positive results. Two researchers independently screened literature and extracted data of included meta-analyses. Then, TSA was performed using TSA software version 0.9 beta. Results A total of 11 meta-analyses were included. The results of TSA showed that, 8 of 11 （72.7%） meta-analyses were potentially false-positive results for failing to surpass the trial sequential monitoring boundary and to reach the required information size. Conclusion TSA can help researchers to identify the false-positive results ofmeta-analyses.

关 键 词：试验序贯分析 META分析 假阳性 COCHRANE系统评价 

分 类 号：R699[医药卫生—泌尿科学]