IL-35与呼吸道变态反应性疾病的研究进展  

Progress on the relationship between IL-35 and respiratory allergic disease

作　　者：李军[1] 黄江菊[1] 

机构地区：[1]重庆医科大学附属第一医院耳鼻咽喉头颈外科,重庆400016

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第7期568-571,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：1997年,Devergne等[1]在研究EB病毒诱导基因3（Epstein Barr virus induced gene 3,EBI3）和IL-12P40亚基时发现,EBI3与P35能相互促进呈高相关性表达,是一种新型异源二聚体。Collison等[2]在2007年首先报道了EBI3与P35异源二聚体的结构及其免疫抑制功能,随后将其正式命名为IL-35,与IL-12、IL-23、IL-27等共同归属于IL-12家族。Interleukin 35（IL-35）,a new IL-12 family cytokine,is consisting of IL-12P35 and Epstein-Barr virus-induced gene 3（EBI3）and is required by regulatory T cells（Tregs）for maximal activity.IL-35 is regarded as apromising new type of anti-inflammatory treatment factor,by the in-vitro and mouse models studies confirmed,although the studies have not been able to elucidate the role of IL-35 in human respiratory allergic disease.This paper describes the IL-35 and respiratory allergic diseases of bronchial asthma,allergic rhinitis and research progress in nasal polyps.

关 键 词：IL-35 IL-12家族 哮喘 鼻炎 变应性 鼻息肉 免疫治疗 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]