慢性阻塞性肺疾病海马1H-MRS成像研究  

1H-MRS measurement of the hippocampus in chronic obstructive pulmonary disease

作　　者：王存强[1] 谭西英[2] 王宇[3] 贺顺岭 顾韵泽 原子扬 

机构地区：[1]新乡市第一人民医院 磁共振科,河南 新乡453000 [2]新乡市第一人民医院 神经内科,河南 新乡453000 [3]新乡市第一人民医院 呼吸内科,河南 新乡453000

出　　处：《实用放射学杂志》2017年第4期500-502,共3页Journal of Practical Radiology

摘　　要：目的 研究慢性阻塞性肺疾病（COPD）患者海马氢质子磁共振波谱（1H-MRS）的特点.方法 随机选取32例COPD患者和30例健康志愿者分别纳入研究组和对照组.采用1H-MRS检测双侧海马的N-乙酰基天门冬氨酸（NAA）、胆碱复合物（Cho）和肌酸复合物（Cr）.结果 研究组左右侧海马NAA/Cr值均显著低于对照组,差异有统计学意义（t=4.963,P=0.007和t=4.856,P=0.023）;研究组左右侧海马Cho/Cr值均显著高于对照组,差异有统计学意义（t=3.469,P=0.013和t=3.019,P=0.047）.结论 COPD患者存在海马神经元的代谢异常.Objective To identify the features of 1H-magnetic resonance spectroscopy（1H-MRS） in patients with chronic obstructive pulmonary disease（COPD） of the hippocampus.Methods 32 patients with COPD randomly selected and 30 normal controls were selected.1H-MRS of the hippocampus was performed given to on all the subjects on hippocampus.The ratios of NAA/Cr and Cho/Cr were determined.Results In the bilateral hippocampus, the NAA/Cr ratio in patients with COPD demonstrated lower than that in normal controls（t=4.963,P=0.007 and t=4.856,P=0.023）.The Cho/Cr ratio in patients with COPD showed higher than that in normal controls, the differences was were statistically significant（t=3.469,P=0.013 and t=3.019,P=0.047） Conclusion Abnormal metabolism of neurons on the hippocampus in patients with COPD is showed.

关 键 词：慢性阻塞性肺疾病 氢质子磁共振波谱 海马 

分 类 号：R563[医药卫生—呼吸系统] R445.2[医药卫生—内科学]