IVIM-MRI监测白兔肾积水肾功能损害的研究  

A study on impairment of renal function in hydronephrosis monitored byintravoxel incoherent motion MR imaging

作　　者：岑人丽[1] 陈娇香[2] 邹乔[1] 叶永胜[1] 伍筱梅[1] 李新春[1] 张文浩[1] 蒙秋华[1] 

机构地区：[1]广州医科大学附属第一医院放射科,广东 广州510120 [2]中山大学附属第一医院胸外科,广东 广州510080

出　　处：《实用放射学杂志》2017年第4期611-614,621,共5页Journal of Practical Radiology

基　　金：广东省医学科研基金项目（A2015403）;广东省科技计划项目（2014A020212353）;广州市属高校科研项目（1201420047）.

摘　　要：目的 探讨体素内不相干运动磁共振成像（IVIM-MRI）监测肾积水肾功能改变的价值.方法 动态分析新西兰大白兔左侧输尿管不全梗阻肾积水模型成模后4、8、12、16周的左肾IVIM-MRI定量参数[表观扩散系数（ADC）值、纯扩散系数（D）值、假性扩散系数（D＊）值、灌注分数（f）值]变化特点,并将该参数与核素肾小球滤过率（GFR）值做相关分析.结果 成模后4、8、12、16周白兔左侧积水肾的皮髓质D值、D＊值、f值、ADC值随着肾功能受损程度加重数值逐步下降,其中D值、f值及ADC值组间两两LSD对比：12周、16周与对照组、4周,8周与16周组间差异有统计学意义（P＜0.05）;D＊值组间两两LSD对比：8周、12周、16周与对照组、4周,12周、16周与8周间差异有统计学意义（P＜0.05）;左侧积水肾成模后不同时间点的D值、D＊值、f值、ADC值与核素GFR呈中度正相关.结论 IVIM-MRI能有效动态监测肾积水肾功能的变化.Objective To investigate the value of intravoxel incoherent motion MR imaging （IVIM-MRI）on monitoring impairment of renal function in hydronephrosis.Methods Left hydronephrosis model of Healthy New-Zealand rabbits made by ureteral incomplete obstruction were scanned by IVIM-MRI at 4, 8, 12, and 16 weeks.The change of IVIM-MRI quantitative parameters （ADC values, D values, D＊ values, and f values） in left hydronephrosis kidney were observed.The correlation between these parameters and glomerular filtration rate （GFR） were evaluated.Results ADC values, D values, D＊ values and f values at cortex and medulla in left hydronephrosis model of rabbits decreased gradually in the progression of renal damage after 4, 8, 12, and 16 weeks.For D value, f value and ADC values, there was statistical significant difference among the group of 12 weeks, the group of 16 weeks, the control group, and the group of 4 weeks;statistical significant difference was also observed between the group of 8 weeks and the group of 16 weeks by LSD contrast.ADC values, D values, D＊ values, and f values were positively correlated to GFR at 4, 8, 12, and 16 weeks for left hydronephrosis model of rabbits.Conclusion IVIM-MRI could monitor impairment of renal function in hydronephrosis dynamically.

关 键 词：磁共振成像 体素内不相干运动 肾积水 肾功能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R692.2[医药卫生—诊断学]